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Eric P. Hoffman
Researcher at Children's National Medical Center
Publications - 16
Citations - 378
Eric P. Hoffman is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Skeletal muscle & Critical Illness Myopathy. The author has an hindex of 8, co-authored 16 publications receiving 329 citations. Previous affiliations of Eric P. Hoffman include State University of New York System & Halifax.
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Journal ArticleDOI
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects
Christopher R. Heier,Jesse M. Damsker,Qing Yu,Blythe C. Dillingham,Tony Huynh,Jack H. Van der Meulen,Arpana Sali,Brittany K. Miller,Aditi Phadke,Luana Scheffer,James L Quinn,Kathleen Tatem,Sarah Jordan,Sherry Dadgar,Olga Rodriguez,Chris Albanese,Michael E. Calhoun,Heather Gordish-Dressman,Jyoti K. Jaiswal,Edward M. Connor,John M. McCall,Eric P. Hoffman,Erica K.M. Reeves,Kanneboyina Nagaraju +23 more
TL;DR: Successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects is demonstrated, indicating VBP15 merits clinical investigation for DMD and would benefit other chronic inflammatory diseases.
Journal ArticleDOI
Gene expression and muscle fiber function in a porcine ICU model
Varuna C. Banduseela,Julien Ochala,Yi-Wen Chen,Yi-Wen Chen,Hanna Göransson,Holly S. Norman,Holly S. Norman,Peter J. Radell,Lars Eriksson,Eric P. Hoffman,Eric P. Hoffman,Lars Larsson,Lars Larsson +12 more
TL;DR: This is the first study that isolates the effect of immobilization and mechanical ventilation in an ICU condition from various other cofactors and proposes that HSP induction in skeletal muscle is an inherent, primary, but temporary protective mechanism against protein degradation.
Journal ArticleDOI
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Christopher R. Heier,Christopher R. Heier,Qing Yu,Alyson A. Fiorillo,Alyson A. Fiorillo,Christopher B. Tully,Asya Tucker,Davi A. G. Mázala,Kitipong Uaesoontrachoon,Sadish Srinivassane,Jesse M. Damsker,Eric P. Hoffman,Eric P. Hoffman,Kanneboyina Nagaraju,Kanneboyina Nagaraju,Christopher F. Spurney,Christopher F. Spurney +16 more
TL;DR: It is found that genetic dystrophin loss provides a second hit for MR-mediated cardiomyopathy in Duchenne muscular dystrophy model mice, as aldosterone worsens fibrosis, mass and dysfunction phenotypes.
Journal ArticleDOI
Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model
Sudhakar Aare,Julien Ochala,Holly S. Norman,Holly S. Norman,Peter J. Radell,Lars Eriksson,Hanna Göransson,Yi-Wen Chen,Yi-Wen Chen,Eric P. Hoffman,Eric P. Hoffman,Lars Larsson,Lars Larsson +12 more
TL;DR: Acute quadriplegic myopathy (AQM) is a common debilitating acquired disorder in critically ill intensive care unit (ICU) patients which is characterized by tetraplegia/generalized weakness of limb as discussed by the authors.
Journal ArticleDOI
Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle.
Varuna C. Banduseela,Yi-Wen Chen,Yi-Wen Chen,Hanna Göransson Kultima,Holly S. Norman,Holly S. Norman,Sudhakar Aare,Peter J. Radell,Lars Eriksson,Eric P. Hoffman,Eric P. Hoffman,Lars Larsson,Lars Larsson +12 more
TL;DR: A novel finding in this study is impaired core autophagy machinery in response to critical illness interventions, which when in concert with downregulated chaperone expression and protein synthesis may collectively affect the proteostasis in skeletal muscle and may exacerbate the disease progression in CIM.