Eric Powell

TL;DR: It is shown that loss of the Drosophila Toll receptor adaptor dSarm cell-autonomously suppresses Wallerian degeneration for weeks after axotomy, providing direct evidence that axons actively promote their own destruction after injury and identify dSARM/Sarm1 as a member of an ancient axon death signaling pathway.

TL;DR: Three independent genome‐wide association studies (GWAS) have investigated the genetic susceptibility to PD and implicated several genes as PD risk loci with strong, but not genome-wide significant, associations.

TL;DR: It is demonstrated that ANKRD11 localizes mainly to the nuclei of neurons and accumulates in discrete inclusions when neurons are depolarized, suggesting that it plays a role in neural plasticity.

TL;DR: The present study observed and replicated a novel statistically significant association in MTHFD1L, a gene involved in the tetrahydrofolate synthesis pathway that may play a role in the generation of methionine from homocysteine and influence homocy steine-related pathways and as levels of homocy Steine are a significant risk factor for LOAD development.

TL;DR: The relative uniform phenotypes in many patients with CMT make it difficult to decide which of the over 35 known CMT genes are affected in a given patient, and genetic testing decision trees are broadly based on a small number of major subtypes and the observed mutation frequency.