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William K. Scott
Researcher at University of Miami
Publications - 286
Citations - 22204
William K. Scott is an academic researcher from University of Miami. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 64, co-authored 267 publications receiving 20039 citations. Previous affiliations of William K. Scott include Mayo Clinic & Vanderbilt University Medical Center.
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Journal ArticleDOI
Complement factor H variant increases the risk of age-related macular degeneration.
Jonathan L. Haines,Michael A. Hauser,Silke Schmidt,William K. Scott,Lana M. Olson,Paul Gallins,Kylee L. Spencer,Shu Ying Kwan,Maher A. Noureddine,John R. Gilbert,Nathalie Schnetz-Boutaud,Anita Agarwal,Eric A. Postel,Margaret A. Pericak-Vance +13 more
TL;DR: DNA resequencing of the complement factor H gene within this haplotype revealed a common coding variant that significantly increases the risk for AMD with odds ratios between 2.45 and 5.57, which likely explains ∼43% of AMD in older adults.
Journal ArticleDOI
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls,Nathan Pankratz,Christina M. Lill,Chuong B. Do,Dena G. Hernandez,Dena G. Hernandez,Mohamad Saad,Mohamad Saad,Mohamad Saad,Anita L. DeStefano,Anita L. DeStefano,Eleanna Kara,Jose Bras,Manu Sharma,Claudia Schulte,Margaux F. Keller,Sampath Arepalli,Christopher Letson,Connor Edsall,Hreinn Stefansson,Xinmin Liu,Hannah A. Pliner,Joseph H. Lee,Rong Cheng,M. Arfan Ikram,John P. A. Ioannidis,Georgios M. Hadjigeorgiou,Joshua C. Bis,Maria Martinez,Maria Martinez,Joel S. Perlmutter,Alison Goate,Karen Marder,Brian K. Fiske,Margaret Sutherland,Georgia Xiromerisiou,Richard H. Myers,Lorraine N. Clark,Kari Stefansson,John Hardy,Peter Heutink,Honglei Chen,Nicholas W. Wood,Henry Houlden,Haydeh Payami,Alexis Brice,Alexis Brice,William K. Scott,Thomas Gasser,Lars Bertram,Nicholas Eriksson,Tatiana Foroud,Andrew B. Singleton +52 more
TL;DR: This article conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls.
Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Seven new loci associated with age-related macular degeneration
Lars G. Fritsche,Lars G. Fritsche,Wei Chen,Wei Chen,Matthew Schu,Brian L. Yaspan,Yi Yu,Gudmar Thorleifsson,Donald J. Zack,Donald J. Zack,Satoshi Arakawa,Valentina Cipriani,Valentina Cipriani,Stephan Ripke,Stephan Ripke,Robert P. Igo,Gabriëlle H.S. Buitendijk,Xueling Sim,Xueling Sim,Daniel E. Weeks,Robyn H. Guymer,Joanna E. Merriam,Peter J. Francis,Gregory Hannum,Anita Agarwal,Ana Maria Armbrecht,Isabelle Audo,Tin Aung,Tin Aung,Gaetano R. Barile,Mustapha Benchaboune,Alan C. Bird,Alan C. Bird,Paul N. Bishop,Kari Branham,Matthew Brooks,Alexander J. Brucker,William Cade,Melinda Cain,Peter A. Campochiaro,Chi-Chao Chan,Ching-Yu Cheng,Ching-Yu Cheng,Emily Y. Chew,Kimberly A Chin,Itay Chowers,David Clayton,Radu Cojocaru,Yvette P. Conley,Belinda K. Cornes,Mark J. Daly,Baljean Dhillon,Albert O. Edwards,Evangelos Evangelou,Jesen Fagerness,Jesen Fagerness,Henry Ferreyra,James S. Friedman,Asbjorg Geirsdottir,Ronnie George,Christian Gieger,Neel Gupta,Stephanie A. Hagstrom,Simon P. Harding,Christos Haritoglou,John R. Heckenlively,Frank G. Holz,Guy Hughes,John P. A. Ioannidis,Tatsuro Ishibashi,Peronne Joseph,Gyungah Jun,Yoichiro Kamatani,Nicholas Katsanis,Claudia N. Keilhauer,Jane C. Khan,Jane C. Khan,Jane C. Khan,Ivana K. Kim,Yutaka Kiyohara,Barbara E.K. Klein,Ronald Klein,Jaclyn L. Kovach,Igor Kozak,Clara Lee,Kristine E. Lee,Peter Lichtner,Andrew J. Lotery,Thomas Meitinger,Paul Mitchell,Saddek Mohand-Said,Anthony T. Moore,Anthony T. Moore,Denise J. Morgan,Margaux A. Morrison,Chelsea E. Myers,Adam C. Naj,Yusuke Nakamura,Yukinori Okada,Anton Orlin,M. Carolina Ortube,Mohammad Othman,Chris Pappas,Kyu Hyung Park,Gayle J.T. Pauer,Neal S. Peachey,Neal S. Peachey,Olivier Poch,Rinki Ratna Priya,Robyn Reynolds,Andrea J. Richardson,Raymond Ripp,G. Rudolph,Euijung Ryu,José-Alain Sahel,Debra A. Schaumberg,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Stephen G. Schwartz,William K. Scott,Humma Shahid,Humma Shahid,Haraldur Sigurdsson,Giuliana Silvestri,Theru A. Sivakumaran,R. Theodore Smith,Lucia Sobrin,Eric H Souied,Dwight Stambolian,Hreinn Stefansson,Gwen M. Sturgill-Short,Atsushi Takahashi,Nirubol Tosakulwong,Barbara Truitt,Evangelia E. Tsironi,André G. Uitterlinden,Cornelia M. van Duijn,Lingam Vijaya,Johannes R. Vingerling,Eranga N. Vithana,Eranga N. Vithana,Andrew R. Webster,Andrew R. Webster,H.-Erich Wichmann,Thomas W. Winkler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Alan F. Wright,Diana Zelenika,Ming Zhang,Ming Zhang,Ling Zhao,Kang Zhang,Kang Zhang,Michael L. Klein,Gregory S. Hageman,Mark Lathrop,Kari Stefansson,Kari Stefansson,Rando Allikmets,Paul N. Baird,Michael B. Gorin,Jie Jin Wang,Jie Jin Wang,Caroline C W Klaver,Johanna M. Seddon,Margaret A. Pericak-Vance,Sudha K. Iyengar,John R.W. Yates,John R.W. Yates,John R.W. Yates,Anand Swaroop,Anand Swaroop,Bernhard H. F. Weber,Michiaki Kubo,Margaret M. DeAngelis,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Jonathan L. Haines,Lindsay A. Farrer,Iris M. Heid,Gonçalo R. Abecasis +185 more
TL;DR: A collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry, identifies 19 loci associated at P < 5 × 10−8, which show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis.
Journal ArticleDOI
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza,Cyrus P. Zabetian,Cyrus P. Zabetian,Albert Tenesa,Alain Laederach,Jennifer S. Montimurro,Dora Yearout,Dora Yearout,Dora Yearout,Denise M. Kay,Kimberly F. Doheny,Justin Paschall,Elizabeth W. Pugh,Victoria I. Kusel,Randall V. Collura,John W. Roberts,Alida Griffith,Ali Samii,Ali Samii,William K. Scott,John G. Nutt,Stewart A. Factor,Haydeh Payami,Haydeh Payami +23 more
TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.