E
Eric Weterings
Researcher at University of Arizona
Publications - 19
Citations - 2142
Eric Weterings is an academic researcher from University of Arizona. The author has contributed to research in topics: Non-homologous end joining & DNA repair. The author has an hindex of 14, co-authored 19 publications receiving 2021 citations. Previous affiliations of Eric Weterings include Nevada Cancer Institute & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
Naoya Uematsu,Eric Weterings,Ken Ichi Yano,Keiko Morotomi-Yano,Burkhard Jakob,Gisela Taucher-Scholz,Pierre Olivier Mari,Dik C. van Gent,Benjamin P C Chen,David J. Chen +9 more
TL;DR: A model in which DNA-PKCS phosphorylation/autophosphorylation facilitates NHEJ by destabilizing the interaction of DNA- PKCS with the DNA ends is suggested.
Journal ArticleDOI
The endless tale of non-homologous end-joining.
Eric Weterings,David J. Chen +1 more
TL;DR: In this review, all the known enzymes that play a role in the NHEJ process are discussed and a working model for the co-operation of these enzymes during DSB repair is presented.
Journal ArticleDOI
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair
Wouter de Laat,Esther Appeldoorn,Kaoru Sugasawa,Eric Weterings,Nicolaas G. J. Jaspers,Jan H.J. Hoeijmakers +5 more
TL;DR: HRPA binds ssDNA with a defined polarity; a strong ssDNA interaction domain of hRPA is positioned at the 5' side of its binding region, a weak ssDNA-binding domain resides at the 3' side.
Journal ArticleDOI
The mechanism of non-homologous end-joining: a synopsis of synapsis.
Eric Weterings,Dik C. van Gent +1 more
TL;DR: This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.
Journal ArticleDOI
Ku recruits XLF to DNA double-strand breaks.
Ken Ichi Yano,Keiko Morotomi-Yano,Shih Ya Wang,Naoya Uematsu,Kyung Jong Lee,Aroumougame Asaithamby,Eric Weterings,David J. Chen +7 more
TL;DR: Observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition.