E
Erika Seemüller
Researcher at Max Planck Society
Publications - 15
Citations - 3239
Erika Seemüller is an academic researcher from Max Planck Society. The author has contributed to research in topics: Proteasome & Thermoplasma acidophilum. The author has an hindex of 14, co-authored 15 publications receiving 3156 citations.
Papers
More filters
Journal ArticleDOI
The proteasome - paradigm of a self-compartmentalizing protease
TL;DR: The work of one of us (W. B.) was supported by a grant of the Human Frontiers Science Program and the wish to thank Drs.
Journal ArticleDOI
Proteasome from Thermoplasma acidophilum: A threonine protease
TL;DR: The catalytic mechanism of the 20S proteasome from the archaebacterium Thermoplasma acidophilum has been analyzed by site-directed mutagenesis of the beta subunit and by inhibitor studies, and data show that the nucleophilic attack is mediated by the amino-terminal threonine of processed beta subunits.
Journal ArticleDOI
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation.
TL;DR: Substrate binding activates ATP hydrolysis, which promotes three processes: substrate unfolding, gate opening in the 20S, and protein translocation.
Journal ArticleDOI
Autocatalytic processing of the 20S proteasome
TL;DR: It is shown that propeptide processing in the proteasome from Thermoplasma acidophilum is indeed autocatalytic, but is probably intermolecular.
Journal ArticleDOI
The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme.
Harald Hölzl,Barbara Kapelari,Josef Kellermann,Erika Seemüller,Máté Sümegi,Andor Udvardy,Ohad Medalia,Joseph Sperling,Shirley A. Müller,Andreas Engel,Wolfgang Baumeister +10 more
TL;DR: Analysis of EM images of 26S proteasomes-UCH-inhibitor complexes allowed for the first time to localize one of the RC's specific functions, deubiquitylating activity.