Erin E. Chambers

TL;DR: The combination of polymeric mixed-mode SPE, the appropriate mobile phase pH and UPLC technology provides significant advantages for reducing matrix effects resulting from plasma matrix components and in improving the ruggedness and sensitivity of bioanalytical methods.

TL;DR: Plasma metanephrines measured by LC-MS/MS are a reliable and sensitive test for the biochemical detection of pheochromocytoma.

TL;DR: A mixed-mode solid-phase extraction method and an ultra-performance liquid chromatography tandem mass spectrometry (SPE UPLC-MS/MS) assay for the simultaneous quantitation of amyloid beta peptides from human cerebrospinal fluid (CSF).

TL;DR: To overcome problems associated with immunoassays, liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) has emerged as a critical orthogonal alternative.

TL;DR: Since the reduction of peptide adsorption and the optimization of the injection solvent resulted in a clear and quantifiable signal of the three peptides, optimization of both issues should be considered in the early stage of method development, in particular when the analysis of low-concentration peptide solutions is envisaged.