J
Josef Pannee
Researcher at Sahlgrenska University Hospital
Publications - 40
Citations - 1417
Josef Pannee is an academic researcher from Sahlgrenska University Hospital. The author has contributed to research in topics: Amyloid beta & Population. The author has an hindex of 18, co-authored 38 publications receiving 1104 citations. Previous affiliations of Josef Pannee include University of Gothenburg.
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Journal ArticleDOI
Mass Spectrometry–Based Candidate Reference Measurement Procedure for Quantification of Amyloid-β in Cerebrospinal Fluid
Andreas Leinenbach,Josef Pannee,Thomas Dülffer,Andreas Huber,Tobias Bittner,Ulf Andreasson,Johan Gobom,Henrik Zetterberg,Henrik Zetterberg,Uwe Kobold,Erik Portelius,Kaj Blennow +11 more
TL;DR: This method will help set the value of CSF A β42 in a CRM, which could be used to harmonize Aβ42 assays and facilitate the introduction of general cutoff concentrations for CSFAβ42 in clinical trials and practice.
Journal ArticleDOI
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.
Antoine Leuzy,Konstantinos Chiotis,Steen G. Hasselbalch,Juha O. Rinne,Juha O. Rinne,Alexandre de Mendonça,Markus Otto,Alberto Lleó,Miguel Castelo-Branco,Isabel Santana,Jarkko Johansson,Sarah Anderl-Straub,Christine A. F. von Arnim,Ambros J. Beer,Rafael Blesa,Juan Fortea,Sanna-Kaisa Herukka,Erik Portelius,Josef Pannee,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Agneta Nordberg,Agneta Nordberg +23 more
TL;DR: In this article, the authors assess the agreement between data on cerebral amyloidosis derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloids-β42; and (ii) centrally measured cerebrainsinal fluid amylhead-β 42 using a Meso Scale Discovery enzyme-linked immunosorbent assay.
Journal ArticleDOI
A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.
Josef Pannee,Erik Portelius,Madalina Oppermann,Alan Atkins,Martin Hornshaw,Ingrid Zegers,Peter Højrup,Lennart Minthon,Oskar Hansson,Henrik Zetterberg,Kaj Blennow,Johan Gobom +11 more
TL;DR: The developed assay is sensitive and is not influenced by matrix effects, enabling absolute quantification of Aβ42, Aβ40, and Aβ38 in CSF, while it retains the ability to distinguish AD patients from controls.
Journal ArticleDOI
Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum
Bryan Krastins,Amol Prakash,David A. Sarracino,Dobrin Nedelkov,Eric E. Niederkofler,Urban A. Kiernan,Randall W. Nelson,Maryann Vogelsang,Gouri Vadali,Alejandra Garces,Jennifer N. Sutton,Scott Peterman,Gregory Byram,Bruno Darbouret,Joëlle R. Pérusse,Nabil G. Seidah,Benoit Coulombe,Johan Gobom,Erik Portelius,Josef Pannee,Kaj Blennow,Vathany Kulasingam,Lewis Couchman,Caje Moniz,Mary F. Lopez +24 more
TL;DR: A practical and scalable method for rapid development and deployment of MS-based SRM assays for clinically relevant proteins and measured levels of the target analytes in bona fide clinical samples is presented.
Journal ArticleDOI
CSF Aβ1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardisation.
Julia Kuhlmann,Ulf Andreasson,Josef Pannee,Maria Bjerke,Erik Portelius,Andreas Leinenbach,Tobias Bittner,Magdalena Korecka,Rand Jenkins,Hugo Vanderstichele,Erik Stoops,Piotr Lewczuk,Leslie M. Shaw,Ingrid Zegers,Heinz Schimmel,Henrik Zetterberg,Kaj Blennow +16 more
TL;DR: A working group for CSF proteins (WG-CSF) has initiated to facilitate standardisation of CSF Aβ1-42 measurement results, including the development of certified reference materials (CRMs) and reference measurement procedures (RMPs) for key biomarkers.