Errol Zeiger

TL;DR: A sensitive in vitro test protocol that was applicable to large-scale chemical screening and yielded comparable results in two laboratories and by testing up to a maximum dose, limited by solubility and/or toxicity, should detect a high proportion of clastogens and SCE inducers.

TL;DR: In this paper, a trend test for evidence of a dose response is proposed for such SCE data, where the percent of cells with chromosome aberrations is the response of interest, and Monte Carlo methods are used to show that the trend test is more sensitive than four other statistical procedures considered for the analysis of Poisson-distributed SCE.

TL;DR: Four widely used in vitro assays for genetic toxicity were investigated for their ability to predict the carcinogenicity of chemicals evaluated in long-term rodent studies by the National Toxicology Program (NTP), and Salmonella performed best.

TL;DR: The in vitro DNA-modifying activity of 2-nitropropane is demonstrated, and evidence is presented to suggest that genetic activity of this nitroalkane may not be dependent on the enzymic reduction of the nitro function to the corresponding hydroxylamine.

TL;DR: Different test results have been reported for the same chemicals in two in vitro chromosome aberration test systems, CHL cells tested by a Japanese protocol and CHO cells by the US National Toxicology Program [Sofuni et al, Mutat Res 241:173-213, 1990].