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Antonella Mangraviti
Researcher at Johns Hopkins University School of Medicine
Publications - 50
Citations - 2326
Antonella Mangraviti is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 19, co-authored 44 publications receiving 1664 citations. Previous affiliations of Antonella Mangraviti include Catholic University of the Sacred Heart & Johns Hopkins University.
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Journal ArticleDOI
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.
Journal ArticleDOI
Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas
Jennifer E. Kim,Mira A. Patel,Antonella Mangraviti,Eileen S. Kim,Debebe Theodros,Esteban Velarde,Ann Liu,Eric W. Sankey,Ada Tam,Haiying Xu,Dimitrios Mathios,Christopher M. Jackson,Sarah Harris-Bookman,Tomas Garzon-Muvdi,Mary Sheu,Allison Martin,Betty Tyler,Phuoc T. Tran,Xiaobu Ye,Alessandro Olivi,Janis M. Taube,Peter C. Burger,Charles G. Drake,Henry Brem,Drew M. Pardoll,Michael Lim +25 more
TL;DR: This is the first preclinical investigation on the effects of dual PD-1 and TIM-3 blockade with radiation and provides preclinical evidence for a novel treatment combination that can potentially result in long-term glioma survival and constitutes a novel immunotherapeutic strategy for the treatment of glioblastoma multiforme.
Journal ArticleDOI
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.
Dimitrios Mathios,Jennifer E. Kim,Antonella Mangraviti,Jillian Phallen,Chul-Kee Park,Chul-Kee Park,Christopher M. Jackson,Tomas Garzon-Muvdi,Eileen Kim,Debebe Theodros,Magdalena J. Polanczyk,Allison Martin,Ian Suk,Xiaobu Ye,Betty Tyler,Chetan Bettegowda,Henry Brem,Drew M. Pardoll,Michael Lim +18 more
TL;DR: It is shown that LC combined with anti-programmed cell death protein 1 (PD-1) facilitates an antitumor immune response and improves survival in glioblastoma and this study suggests that both mode of delivery and timing have distinct effects on the efficacy of anti- PD-1.
Journal ArticleDOI
Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo
Antonella Mangraviti,Stephany Y. Tzeng,Kristen L. Kozielski,Yuan Wang,Yuan Wang,Yike Jin,David Gullotti,Mariangela Pedone,Nitsa Buaron,Nitsa Buaron,Ann Liu,David R. Wilson,Sarah K. Hansen,Fausto J. Rodriguez,Guo Dong Gao,Francesco DiMeco,Henry Brem,Alessandro Olivi,Betty Tyler,Jordan J. Green +19 more
TL;DR: This study synthesizes and characterize polymeric gene delivery nanoparticles and evaluates their efficacy for DNA delivery of herpes simplex virus type I thymidine kinase combined with the prodrug ganciclovir in a malignant glioma model.
Journal ArticleDOI
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival
Antonella Mangraviti,Stephany Y. Tzeng,David Gullotti,Kristen L. Kozielski,Jennifer E. Kim,Michael Seng,Sara Abbadi,Paula Schiapparelli,Rachel Sarabia-Estrada,Angelo L. Vescovi,Henry Brem,Alessandro Olivi,Betty Tyler,Jordan J. Green,Alfredo Quiñones-Hinojosa +14 more
TL;DR: It is demonstrated that synthetic polymeric nanoparticles are a safe and effective approach for stem cell-based cancer-targeting therapies and can overcome a central challenge for brain therapeutics, overcoming the blood brain barrier.