Lorenza Nisticò

TL;DR: In this article, the authors described linkage and association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte associated-4) on chromosome 2q33 (designated IDDM12), which is a strong candidate gene for T cell mediated autoimmune disease because it encodes a T cell receptor that mediates T cell apoptosis and is a vital negative regulator of T cell activation.

TL;DR: The results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men.

TL;DR: The utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases is demonstrated, with evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152.

TL;DR: MZ pairs have a high probability of being concordant, regardless of sex or HLA genotype, and most of the affected co-twins receive a diagnosis within two years.

TL;DR: It is demonstrated that a particular class I allele does not predispose to disease when paternally inherited, suggestive of polymorphic imprinting, and this paternal effect is observed only when the father's untransmitted allele is a class III.