L
Lionel Frangeul
Researcher at Pasteur Institute
Publications - 69
Citations - 11426
Lionel Frangeul is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 36, co-authored 65 publications receiving 10638 citations. Previous affiliations of Lionel Frangeul include Centre national de la recherche scientifique.
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Journal ArticleDOI
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Chaysavanh Manichanh,Lionel Rigottier-Gois,Elian Bonnaud,Karine Gloux,Eric Pelletier,Lionel Frangeul,Renaud Nalin,Cyrille Jarrin,Patrick Chardon,Phillipe Marteau,Joaquim Roca,Joël Doré +11 more
TL;DR: The metagenomic approach allowed us to detect a reduced complexity of the bacterial phylum Firmicutes as a signature of the faecal microbiota in patients with CD, and indicated the presence of new bacterial species.
Journal ArticleDOI
Genome evolution in yeasts
Bernard Dujon,David James Sherman,Gilles Fischer,Pascal Durrens,Serge Casaregola,Ingrid Lafontaine,Jacky de Montigny,Christian Marck,Cécile Neuvéglise,Emmanuel Talla,Nicolas Goffard,Lionel Frangeul,Michel Aigle,Véronique Anthouard,Anna Babour,Valérie Barbe,Stéphanie Barnay,Sylvie Blanchin,Jean-Marie Beckerich,Emmanuelle Beyne,Claudine Bleykasten,Anita Boisramé,Jeanne Boyer,Laurence Cattolico,Fabrice Confanioleri,Antoine de Daruvar,Laurence Despons,Emmanuelle Fabre,Cécile Fairhead,Hélène Ferry-Dumazet,Alexis Groppi,Florence Hantraye,Christophe Hennequin,Nicolas Jauniaux,Philippe Joyet,Rym Kachouri,Alix Kerrest,Romain Koszul,Marc Lemaire,Isabelle Lesur,Laurence Ma,Héloïse Muller,Jean-Marc Nicaud,Macha Nikolski,Sophie Oztas,Odile Ozier-Kalogeropoulos,Stefan Pellenz,Serge Potier,Guy-Franck Richard,Marie-Laure Straub,Audrey Suleau,Dominique Swennen,Fredj Tekaia,Micheline Wésolowski-Louvel,Eric Westhof,Bénédicte Wirth,Maria Zeniou-Meyer,Ivan Zivanovic,Monique Bolotin-Fukuhara,Agnès Thierry,Christiane Bouchier,Bernard Caudron,Claude Scarpelli,Claude Gaillardin,Jean Weissenbach,Patrick Wincker,Jean-Luc Souciet +66 more
TL;DR: Analysis of chromosome maps and genome redundancies reveal that the different yeast lineages have evolved through a marked interplay between several distinct molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication and extensive gene loss.
Journal ArticleDOI
Comparative Genomics of Listeria Species
Philippe Glaser,Lionel Frangeul,Carmen Buchrieser,Christophe Rusniok,Alexandra Amend,Fernando Baquero,Patrick Berche,H Bloecker,P Brandt,Trinad Chakraborty,Alain Charbit,Farid Chetouani,Elisabeth Couvé,A de Daruvar,Pierre Dehoux,Eugen Domann,Gustavo Domínguez-Bernal,Eric Duchaud,Lionel Durant,Olivier Dussurget,K-D Entian,Hafida Fsihi,F García-del Portillo,P. Garrido,Laurent Gautier,Werner Goebel,Nuria Gomez-Lopez,Torsten Hain,Jörg Hauf,D Jackson,L-M Jones,U Kaerst,Jürgen Kreft,Michael Kuhn,F. Kunst,G Kurapkat,Encarnación Madueño,A Maitournam,J Mata Vicente,E Ng,Hafed Nedjari,G Nordsiek,Susana Novella,B de Pablos,José-Claudio Perez-Diaz,R Purcell,B Remmel,Matthias Rose,T Schlueter,N Simoes,A. Tierrez,José A. Vázquez-Boland,Hamut Voss,Jürgen Wehland,Pascale Cossart +54 more
TL;DR: A large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators are found, consistent with the ability of both species to adapt to diverse environments.
Journal ArticleDOI
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Journal ArticleDOI
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens
Eric Duchaud,Christophe Rusniok,Lionel Frangeul,Carmen Buchrieser,Alain Givaudan,Sead Taourit,Stéphanie Bocs,Caroline Boursaux-Eude,Michael Chandler,Jean-François Charles,Elie Dassa,Richard Derose,Sylviane Derzelle,Georges Freyssinet,Sophie Gaudriault,Claudine Médigue,Anne Lanois,Kerrie Powell,Patricia Siguier,Rachel Vincent,Vincent Paul Mary Wingate,Mohamed Zouine,Philippe Glaser,Noël Boemare,Antoine Danchin,Frank Kunst +25 more
TL;DR: Compared with the genomes of related bacteria, the complete genome sequence of strain TT01 reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen.