E
Eugene R. Bleecker
Researcher at University of Maryland, Baltimore
Publications - 35
Citations - 3492
Eugene R. Bleecker is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Asthma & Atopy. The author has an hindex of 22, co-authored 35 publications receiving 3450 citations. Previous affiliations of Eugene R. Bleecker include University of Maryland, College Park.
Papers
More filters
Journal ArticleDOI
Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.
Dirkje S. Postma,Eugene R. Bleecker,PJ Amelung,Kenneth J. Holroyd,Jianfeng Xu,Carolien I.M. Panhuysen,Deborah A. Meyers,Roy C. Levitt +7 more
TL;DR: It is demonstrated that a trait for an elevated level of serum total IgE is coinherited with a traits for bronchial hyperresponsiveness and that a gene governing bronchiahyperresponsiveness is located near a major locus that regulates serum IgE levels on chromosome 5q.
Journal ArticleDOI
A genome-wide search for asthma susceptibility loci in ethnically diverse populations
David G. Marsh,Nancy E. Maestri,Linda R. Freidhoff,Kathleen C. Barnes,Alkis Togias,Eva Ehrlich,Terri H. Beaty,David L. Duffy,Richard R. Rosenthal,Farhad Imani,Georgia M. Dunston,Paulette Furbert-Harris,Floyd J. Malveaux,Carole Ober,Nancy J. Cox,Lucille A. Lester,Rhonda Peterson,Heidi Gidley,Anna Pluzhnikov,Jennifer L. Anderson,Julian Solway,Alan R. Leff,Raoul L. Wolf,Mark Wylam,Bradley Kurtz,Anthony Richardson,Rodney Parry,Malcolm N. Blumenthal,Richard A. King,William S. Oetting,Delores Drury,Andreas Rosenberg,Lisa R. Daniels,Charlene McEvoy,Jay Lou,Mark Hamra,Marcia J. Brott,Stephen S. Rich,Beverly J. Spray,James L. Weber,Bo Yuan,Zhenyuan Wang,Eugene R. Bleecker,PJ Amelung,Betsy Rechstiner,Deborah A. Meyers,Jonathan M. Samet,Denise Wiesch,Jianfeng Xu,Shirley Murphy,Susan Banks-Schlegel +50 more
TL;DR: A genome-wide search in 140 families with ≥2 asthmatic sibs, from three racial groups and report evidence for linkage to six novel regions, including 5p15 (P= 0.0008) and 17p11.1–q11.2 (/> = 0.0015) in African Americans and 11p15 and 19q13 (P =0.0013) in Caucasians and Hispanics.
Journal ArticleDOI
Evidence for a locus regulating total serum ige levels mapping to chromosome-5
Deborah A. Meyers,Dirkje S. Postma,Carolien I.M. Panhuysen,Jianfeng Xu,PJ Amelung,Roy C. Levitt,Eugene R. Bleecker +6 more
TL;DR: Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score analysis with evidence for recessive inheritance of high IgE levels from segregation analysis, a major step in mapping genes important in the regulation of allergic responses and the pathogenesis of asthma.
Journal ArticleDOI
Variation in the Interleukin 4–Receptor α Gene Confers Susceptibility to Asthma and Atopy in Ethnically Diverse Populations
Carole Ober,Stephanie A. Leavitt,Anya Tsalenko,Timothy D. Howard,Danessa M. Hoki,Rajeev Daniel,Dina L. Newman,Xiaodong Wu,Rodney Parry,Lucille A. Lester,Julian Solway,Malcolm N. Blumenthal,Richard A. King,Jianfeng Xu,Deborah A. Meyers,Eugene R. Bleecker,Nancy J. Cox +16 more
TL;DR: Overall, these data suggest that the IL4RA gene is an atopy- and asthma-susceptibility locus but that variation outside the coding region of the gene influences susceptibility.
Journal ArticleDOI
Relationship Between Airway Obstruction and Respiratory Symptoms in Adult Asthmatics
TL;DR: The results support the recommendation to measure airway obstruction objectively when assessing adult patients with chronic asthma and suggest subjective improvement in asthma symptoms may occur without improvement in the level ofAirway obstruction following treatment.