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Eun-Woo Lee
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 96
Citations - 2429
Eun-Woo Lee is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Ubiquitin ligase & Apoptosis. The author has an hindex of 23, co-authored 89 publications receiving 1649 citations. Previous affiliations of Eun-Woo Lee include Sungkyunkwan University & Yonsei University.
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Journal ArticleDOI
Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
Tae Jun Park,Tae Jun Park,Jei Hyoung Park,Ga Seul Lee,Ji Yoon Lee,Ji Yoon Lee,Ji Hye Shin,Min Wook Kim,Yong Sook Kim,Jeong Yoon Kim,Kyoung Jin Oh,Baek Soo Han,Won Kon Kim,Youngkeun Ahn,Jeong Hee Moon,Jaewhan Song,Kwang-Hee Bae,Do Han Kim,Eun-Woo Lee,Sang Chul Lee +19 more
TL;DR: This study suggests that downregulation of GPX4 during MI contributes to ferroptotic cell death in cardiomyocytes upon metabolic stress such as cysteine deprivation.
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Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer.
Ji Yoon Lee,Ji Yoon Lee,Miso Nam,Hye Young Son,Kwangbeom Hyun,Seo Young Jang,Jong Woo Kim,Min Wook Kim,Youngae Jung,Eunji Jang,Seon Jin Yoon,Jung-Eun Kim,Jihye Kim,Jin-Ho Seo,Jeong Ki Min,Kyoung Jin Oh,Baek Soo Han,Won Kon Kim,Kwang-Hee Bae,Kwang-Hee Bae,Jaewhan Song,Jae-Hoon Kim,Yong Min Huh,Geum-Sook Hwang,Eun-Woo Lee,Sang Chul Lee +25 more
TL;DR: The expression of elongation of very long-chain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) is up-regulated in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization, and the polyunsaturated fatty acid (PUFA) biosynthesis pathway plays an essential role in ferroPTosis.
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Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
Eun-Woo Lee,Min Sik Lee,Suzanne Camus,Jaewang Ghim,Mi Ran Yang,Wonkyung Oh,Nam-Chul Ha,David P. Lane,Jaewhan Song +8 more
TL;DR: The results indicate that MKRN1 exhibits dual functions of keeping cells alive by suppressing p53 under normal conditions and stimulating cell death by repressing p21 under stress conditions.
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CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3
Jin-Ho Seo,Eun-Woo Lee,Hyerim Sung,Daehyeon Seong,Yves Dondelinger,Jihye Shin,Jihye Shin,Manhyung Jeong,Hae Kyung Lee,Jung-Hoon Kim,Su Yeon Han,Cheolju Lee,Je Kyung Seong,Peter Vandenabeele,Jaewhan Song +14 more
TL;DR: It is reported that the RIPK3 expression level is negatively regulated by CHIP (carboxyl terminus of Hsp70-interacting protein; also known as STUB1) E3 ligase-mediated ubiquitylation, validating the major role of CHIP in necrosome formation and sensitivity to TNF-mediated necroptosis.
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The roles of FADD in extrinsic apoptosis and necroptosis
TL;DR: The mechanism of extrinsic apoptosis and necroptosis is summarized, the in vivo and in vitro roles of FADD in necroPTosis induced by various stimuli are discussed, and FADD was shown to be involved in various ne croptosis models.