E
Eunji Kim
Researcher at Ewha Womans University
Publications - 42
Citations - 1467
Eunji Kim is an academic researcher from Ewha Womans University. The author has contributed to research in topics: Streptomyces venezuelae & Medicine. The author has an hindex of 18, co-authored 36 publications receiving 1150 citations. Previous affiliations of Eunji Kim include Texas A&M University.
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Journal ArticleDOI
A Review of the Microbial Production of Bioactive Natural Products and Biologics.
Janette V. Pham,Mariamawit A. Yilma,Adriana Feliz,Murtadha T. Majid,Nicholas Maffetone,Jorge R. Walker,Eunji Kim,Hyo Je Cho,Jared M. Reynolds,Myoung Chong Song,Sung Ryeol Park,Sung Ryeol Park,Yeo Joon Yoon +12 more
TL;DR: The structures and diverse biological activities of natural products and recombinant proteins that have been exploited as valuable molecules in medicine, agriculture and insect control are introduced and suggested to inspire the development of new therapeutic agents in academia and industry.
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Reinvigorating natural product combinatorial biosynthesis with synthetic biology
TL;DR: The current limitations, the realities and the state of the art of combinatorial biosynthesis are discussed, including the engineering of substrate specificity of biosynthetic enzymes and the development of heterologous expression systems for biosynthesis pathways.
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Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues
SangJoon Mo,Dong Hwan Kim,Jong Hyun Lee,Je Won Park,Devi B. Basnet,Yeon Hee Ban,Young Ji Yoo,Shu Wei Chen,Sung Ryeol Park,Eun Ae Choi,Eunji Kim,Ying Yu Jin,Sung Kwon Lee,Ju Yeol Park,Yuan Liu,Mi Ok Lee,Keum Soon Lee,Sang Jun Kim,Dooil Kim,Byoung Chul Park,Sang Gi Lee,Ho Jeong Kwon,Joo Won Suh,Bradley S. Moore,Si Kyu Lim,Yeo Joon Yoon +25 more
TL;DR: This unique feature of FK506 biosynthesis, in which a dedicated PKS provides an atypical extender unit for the main modular PKS, illuminates a new strategy for the combinatorial biosynthesis of designer macrolide scaffolds as well as FK505 analogues.
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Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation
Je Won Park,Je Won Park,Sung Ryeol Park,Keshav K. Nepal,Ah Reum Han,Yeon Hee Ban,Young Ji Yoo,Eunji Kim,Eui Min Kim,Dooil Kim,Jae Kyung Sohng,Yeo Joon Yoon +11 more
TL;DR: It is discovered that the kanamycin biosynthetic pathway contains an early branch point, governed by the substrate promiscuity of a glycosyltransferase, that leads to the formation of two parallel pathways in which early intermediates are further modified.
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Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects
TL;DR: This review highlights the current state of novel macrolide production with a focus on the genetic engineering of PKS and post-PKS tailoring genes, which provides attractive alternatives for the production of diverse non-natural compounds.