M
Margaret A. Kenna
Researcher at Boston Children's Hospital
Publications - 203
Citations - 7932
Margaret A. Kenna is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Hearing loss & Sensorineural hearing loss. The author has an hindex of 45, co-authored 192 publications receiving 6878 citations. Previous affiliations of Margaret A. Kenna include Johns Hopkins University & Lehigh University.
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Journal ArticleDOI
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
Jeffrey S. Smith,Carrie Baker Brachmann,Carrie Baker Brachmann,Ivana Celic,Margaret A. Kenna,Margaret A. Kenna,Shabazz Muhammad,Vincent J. Starai,José L. Avalos,Jorge C. Escalante-Semerena,Charles Grubmeyer,Cynthia Wolberger,Jef D. Boeke +12 more
TL;DR: The yeast Sir2 protein, required for transcriptional silencing, has an NAD+dependent histone deacetylase (HDA) activity that is eliminated in a yeast strain from which SIR2 and its four homologs have been deleted as mentioned in this paper.
Journal ArticleDOI
GJB2 mutations and degree of hearing loss: a multicenter study.
Rikkert L. Snoeckx,Patrick L. M. Huygen,Delphine Feldmann,Sandrine Marlin,Françoise Denoyelle,Jaroslaw Waligora,Małgorzata Mueller-Malesińska,Agneszka Pollak,Rafał Płoski,Alessandra Murgia,Eva Orzan,Pierangela Castorina,Umberto Ambrosetti,Ewa Nowakowska-Szyrwinska,Jerzy Bal,Wojciech Wiszniewski,Andreas R. Janecke,Doris Nekahm-Heis,Pavel Seeman,O. Bendová,Margaret A. Kenna,Anna Frangulov,Heidi L. Rehm,Mustafa Tekin,Armagan Incesulu,Hans Henrik M. Dahl,Desirée du Sart,Lucy Jenkins,Deirdre Lucas,Maria Bitner-Glindzicz,Karen B. Avraham,Zippora Brownstein,Ignacio del Castillo,Felipe Moreno,Nikolaus Blin,Markus Pfister,István Sziklai,Tímea Tóth,Philip M. Kelley,Edward S. Cohn,Lionel Van Maldergem,Pascale Hilbert,Anne Françoise Roux,Michel Mondain,Lies H. Hoefsloot,Cor W. R. J. Cremers,Tuija Löppönen,Heikki Löppönen,Agnete Parving,Karen Grønskov,Iris Schrijver,Joseph B. Roberson,Francesca Gualandi,Alessandro Martini,Geneviève Lina-Granade,Nathalie Pallares-Ruiz,Céu Correia,Graça Fialho,Kim Cryns,Nele Hilgert,Paul Van de Heyning,Carla Nishimura,Richard J.H. Smith,Guy Van Camp +63 more
TL;DR: The association between genotype and degree of hearing loss in persons with HI and biallelic GJB2 mutations was assessed and two genotypes had significantly more-severe HI than that of 35delG homozygotes.
Journal ArticleDOI
Clinical Practice Guideline: Otitis Media with Effusion
Richard M. Rosenfeld,Larry Culpepper,Karen J Doyle,Kenneth M. Grundfast,Alejandro Hoberman,Margaret A. Kenna,Allan S. Lieberthal,Martin C. Mahoney,Richard A. Wahl,Charles R. Woods,Barbara P. Yawn +10 more
TL;DR: The clinical practice guideline on otitis media with effusion (OME) provides evidence-based recommendations on diagnosing and managing OME in children and selected a subcommittee composed of experts in the fields of primary care, otolaryngology, infectious diseases, epidemiology, hearing, speech and language, and advanced practice nursing to revise the OME guideline.
Journal ArticleDOI
Expert specification of the ACMG/AMP variant interpretation guidelines for genetic hearing loss.
Andrea M. Oza,Andrea M. Oza,Marina T. DiStefano,Marina T. DiStefano,Sarah E. Hemphill,Brandon J. Cushman,Andrew R. Grant,Rebecca K. Siegert,Jun Shen,Jun Shen,Jun Shen,Alex Chapin,Nicole J. Boczek,Lisa A. Schimmenti,Jaclyn B. Murry,Linda Hasadsri,Kiyomitsu Nara,Margaret A. Kenna,Margaret A. Kenna,Kevin T. Booth,Kevin T. Booth,Hela Azaiez,Andrew J. Griffith,Karen B. Avraham,Hannie Kremer,Heidi L. Rehm,Sami S. Amr,Sami S. Amr,Sami S. Amr,Ahmad N. Abou Tayoun,Ahmad N. Abou Tayoun +30 more
TL;DR: A comprehensive illustration of the newly specified ACMG/AMP HL rules are provided, which will help standardize variant interpretation, ultimately leading to better care for individuals with HL.
Journal ArticleDOI
Airway foreign bodies (FB): a 10-year review.
Henry K.K. Tan,Karla Brown,Trevor J. McGill,Margaret A. Kenna,Dennis P. Lund,Gerald B. Healy +5 more
TL;DR: A retrospective chart review of children who had airway foreign body removed via direct laryngoscopy and bronchoscopy from 1987-1997 was conducted in Children's Hospital, Boston, finding early diagnosis remains the key to successful and uncomplicated management of foreign body aspiration.