E
Eva Paucha
Researcher at Harvard University
Publications - 5
Citations - 2354
Eva Paucha is an academic researcher from Harvard University. The author has contributed to research in topics: SV40 large T antigen & Immunoprecipitation. The author has an hindex of 5, co-authored 5 publications receiving 2339 citations.
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Journal ArticleDOI
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
James A. DeCaprio,John W. Ludlow,James Figge,Jin-Yuh Shew,Chun-Ming Huang,Wen-Hwa Lee,Erika Marsilio,Eva Paucha,David M. Livingston +8 more
TL;DR: Results are consistent with a model for transformation by SV40 which, at least in part, involves T/p110-114 complex formation and the perturbation of Rb protein and/or T function.
Journal ArticleDOI
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family.
TL;DR: The results suggest a model in which the growth suppression function of Rb is down modulated either by phosphorylation or T antigen binding, and T bound preferentially to the un- or underphosphorylated member of the family.
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An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120
Mark E. Ewen,John W. Ludlow,Erika Marsilio,James A. DeCaprio,Robert C. Millikan,Seng H. Cheng,Eva Paucha,David M. Livingston +7 more
TL;DR: It is suggested that interactions between T and p115/118/120, as well as T and Rb, contribute to the SV40 transforming mechanism.
Journal ArticleDOI
Identification of a region of simian virus 40 large T antigen required for cell transformation.
Shun Hua Chen,Eva Paucha +1 more
TL;DR: The results imply that the sequence from 106 to 114 forms part of a domain that is essential for transformation of established cells, is dispensable for immortalization, and is not required for SV40 replication.
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The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.
TL;DR: Results of stability and transformation assays of these mutants strongly suggest that the 1-to-82 region of T contains sequences which govern T transforming activity and affect in vivo stability.