J
James A. DeCaprio
Researcher at Harvard University
Publications - 236
Citations - 25368
James A. DeCaprio is an academic researcher from Harvard University. The author has contributed to research in topics: Merkel cell carcinoma & Retinoblastoma protein. The author has an hindex of 75, co-authored 217 publications receiving 23432 citations. Previous affiliations of James A. DeCaprio include Institute of Cancer Research & Dana Corporation.
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Journal ArticleDOI
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
James A. DeCaprio,John W. Ludlow,James Figge,Jin-Yuh Shew,Chun-Ming Huang,Wen-Hwa Lee,Erika Marsilio,Eva Paucha,David M. Livingston +8 more
TL;DR: Results are consistent with a model for transformation by SV40 which, at least in part, involves T/p110-114 complex formation and the perturbation of Rb protein and/or T function.
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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
Richard Eckner,Mark E. Ewen,D. Newsome,M Gerdes,James A. DeCaprio,Jeanne B. Lawrence,David M. Livingston +6 more
TL;DR: It is shown that p300 molecules lacking an intact E1A-binding site can bypass E 1A repression and restore to a significant extent the activity of the SV40 enhancer, even in the presence of high levels of E1a protein.
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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.
James A. DeCaprio,John W. Ludlow,Dennis C. Lynch,Yusuke Furukawa,James D. Griffin,Helen Piwnica-Worms,Chun-Ming Huang,David M. Livingston +7 more
TL;DR: The cell cycle-dependent phosphorylation of Rb is demonstrated and a model to explain how Rb may suppress cell growth by acting as a cell cycle regulatory element is proposed.
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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
William G. Kaelin,Wilhelm Krek,William R. Sellers,James A. DeCaprio,Florence Ajchenbaum,Charles S. Fuchs,Thomas Chittenden,Yue Li,Peggy J. Farnham,Michael A. Blanar,David M. Livingston,Erik K. Flemington +11 more
TL;DR: It is found that RBAP-1 copurifies with E2F, interacts specifically with the adenovirus E4 ORF 6/7 protein, binds specifically and directly to a known E2f DNA recognition sequence, and contains a functional tranasactivation domain.
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Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
TL;DR: TGF- beta 1 and RB appear to function in a common growth-inhibitory pathway in which TGF-beta 1 acts to retain RB in the underphosphorylated, growth-suppressive state.