Eva V. Acosta-Rodríguez

TL;DR: It is demonstrated that human TH-17 cells have distinct migratory capacity and antigenic specificities and a link between microbial products, T helper cell differentiation and homing in response to fungal antigens is established.

TL;DR: These results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH- 17 cells in humans and mice.

TL;DR: It is found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.

TL;DR: It is reported here that prostaglandin E2 (PGE2) can directly modulate cytokine production by human memory CD4+ T cells and suggest a novel mechanism by which inhibitors of prostaglandsin synthesis, such as COX‐2 inhibitors, exert their anti‐inflammatory effect.

TL;DR: Evidence is provided of a novel role for Gal-3 as an intracellular mediator of B cell survival and a checkpoint in IL-4-induced B cell commitment toward a memory phenotype.