Laura Rivino

TL;DR: It is demonstrated that human TH-17 cells have distinct migratory capacity and antigenic specificities and a link between microbial products, T helper cell differentiation and homing in response to fungal antigens is established.

TL;DR: It is shown that three chemokine receptors identify functional subsets within the human CD4+ TCM cell pool, which explain how the quality of primary T cell responses could be maintained by TCM cells in the absence of antigen.

TL;DR: During a dengue virus infection, the protein targets of human CD4+ and CD8+ T cells are largely distinct, thus highlighting key differences in the immunodominance of DENV proteins for these two cell types has important implications for understanding how the two arms of the human adaptive immune system are differentially targeted and employed as part of the response to DENV infection.

TL;DR: This study identifies the presence of functional HBV-specific T cells as a candidate immunological biomarker for safe therapy discontinuation in chronic HBV patients and highlights the potential beneficial role of the expression of T cell exhaustion markers during human chronic viral infection.

TL;DR: Although the presence of HBs-specific T cells might not be required for clearance of HBV infection in all patients, strategies to restore anti-HBV immune responses should consider patients younger than 30 years.