E
Evan Lester
Researcher at University of Colorado Boulder
Publications - 14
Citations - 1496
Evan Lester is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: RNA-binding protein & Stress granule. The author has an hindex of 7, co-authored 11 publications receiving 859 citations. Previous affiliations of Evan Lester include Yale University & Anschutz Medical Campus.
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Journal ArticleDOI
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Daniel B. Larremore,Bryan Wilder,Evan Lester,Evan Lester,Soraya Shehata,Soraya Shehata,James M. Burke,James A. Hay,Milind Tambe,Michael J. Mina,Michael J. Mina,Roy Parker +11 more
TL;DR: It is demonstrated that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity, and should prioritize accessibility, frequency, and sample-to-answer time.
Posted ContentDOI
Surveillance testing of SARS-CoV-2
Daniel B. Larremore,Bryan Wilder,Evan Lester,Evan Lester,Soraya Shehata,Soraya Shehata,James M. Burke,James A. Hay,Milind Tambe,Michael J. Mina,Michael J. Mina,Roy Parker +11 more
TL;DR: It is concluded that surveillance should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary.
Journal ArticleDOI
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
Thomas O. Vogler,Thomas O. Vogler,Joshua Wheeler,Joshua Wheeler,Eric D. Nguyen,Michael P. Hughes,Kyla A. Britson,Evan Lester,Evan Lester,Bhalchandra S. Rao,Nicole Dalla Betta,Oscar N. Whitney,Theodore Eugene Ewachiw,Edward Gomes,James Shorter,Thomas E. Lloyd,David Eisenberg,J. Paul Taylor,Aaron M. Johnson,Bradley B. Olwin,Roy Parker,Roy Parker +21 more
TL;DR: It is shown that TDP-43 is an essential protein for normal skeletal muscle formation that unexpectedly forms cytoplasmic, amyloid-like oligomeric assemblies, which the authors call myo-granules, during regeneration of skeletal muscle in mice and humans.
Journal ArticleDOI
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Evan Lester,Felicia K. Ooi,Nadine Bakkar,Jacob I. Ayers,Amanda L. Woerman,Joshua Wheeler,Robert Bowser,George A. Carlson,Stanley B. Prusiner,Roy Parker,Roy Parker +10 more
TL;DR: In this article, the authors demonstrate that cytosolic and nuclear tau aggregates contain RNA with enrichment for small nuclear RNAs (snRNAs) and small nucleolar RNAs(snoRNAs).
Journal ArticleDOI
RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules
TL;DR: It is demonstrated that RLBs represent a unique RNP granule with a protein and RNA composition distinct from that of SGs in response to dsRNA lipofection in human cells, and that RNase L promotes the formation of aunique RNP complex that may have roles during theRNase L–mediated antiviral response.