T
Thomas E. Lloyd
Researcher at Johns Hopkins University School of Medicine
Publications - 130
Citations - 7146
Thomas E. Lloyd is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Myositis. The author has an hindex of 36, co-authored 105 publications receiving 5666 citations. Previous affiliations of Thomas E. Lloyd include Fiona Stanley Hospital & Baylor College of Medicine.
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Journal ArticleDOI
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Ke Zhang,Christopher J. Donnelly,Aaron R. Haeusler,Jonathan C. Grima,James B. Machamer,Peter Steinwald,Elizabeth L. Daley,Sean J. Miller,Kathleen M. Cunningham,Svetlana Vidensky,Saksham Gupta,Michael A. Thomas,Ingie Hong,Shu Ling Chiu,Richard L. Huganir,Lyle W. Ostrow,Michael J. Matunis,Jiou Wang,Rita Sattler,Thomas E. Lloyd,Jeffrey D. Rothstein +20 more
TL;DR: Nuclear import is impaired as a result of HRE expression in the fly model and in C9orf72 iPSC-derived neurons, and these deficits are rescued by small molecules and antisense oligonucleotides targeting the HRE G-quadruplexes.
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Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila
TL;DR: Electron microscopy studies of hrs mutant larvae reveal an impairment in endosome membrane invagination and formation of multivesicular bodies (MVBs), and data suggest that Hrs and MVB formation function to downregulate TKR signaling.
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Endophilin Mutations Block Clathrin-Mediated Endocytosis but Not Neurotransmitter Release
Patrik Verstreken,Ole Kjaerulff,Thomas E. Lloyd,Richard Atkinson,Yi Zhou,Ian A. Meinertzhagen,Hugo J. Bellen +6 more
TL;DR: It is proposed that kiss-and-run maintains neurotransmission at active zones of the larval NMJ in endophilin animals with mutant larvae that fail to take up FM1-43 dye in synaptic bouts, indicating an inability to retrieve synaptic membrane.
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Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
Ke Zhang,J. Gavin Daigle,Kathleen M. Cunningham,Alyssa N. Coyne,Kai Ruan,Jonathan C. Grima,Kelly Bowen,Harsh Wadhwa,Peiguo Yang,Frank Rigo,J. Paul Taylor,Aaron D. Gitler,Jeffrey D. Rothstein,Thomas E. Lloyd +13 more
TL;DR: It is demonstrated that inhibiting stress granule assembly, such as by knocking down Ataxin-2, suppresses nucleocytoplasmic transport defects as well as neurodegeneration in C9ORF72-mediated ALS/FTD.
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Mutant Huntingtin Disrupts the Nuclear Pore Complex
Jonathan C. Grima,J. Gavin Daigle,Nicolas Arbez,Kathleen C. Cunningham,Ke Zhang,Joseph Ochaba,Charlene Geater,Eva L. Morozko,Jennifer Stocksdale,Jenna C. Glatzer,Jacqueline T. Pham,Ishrat Ahmed,Qi Peng,Harsh Wadhwa,Olga Pletnikova,Juan C. Troncoso,Wenzhen Duan,Solomon H. Snyder,Laura P.W. Ranum,Leslie M. Thompson,Thomas E. Lloyd,Christopher A. Ross,Jeffrey D. Rothstein +22 more
TL;DR: This work evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, including mouse and fly models, neurons transfected with mHTT, HD iPSC-derived neurons, and human HD brain regions, and revealed severe mislocalization and aggregation of NUPs and defective nucleocy toplasmi transport.