Evelyne Jacqz-Aigrain

TL;DR: It is proposed that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations.

TL;DR: The purpose of this study was to determine the risk factors for sepsis, the causative organisms, and mortality following infection in a large and diverse sample of NICUs, and to conclude that overall mortality in VLBW infants with early- and late-onset sepsi is higher than in infants with negative cultures.

TL;DR: The rise in CYP2D6 protein was associated with the developmental onset of dextromethorphan O-dem methylation, but not N-demethylation, even if activity was lower in fetal than in neonatal and in adult liver microsomes, suggesting that regulation is primarily at the transcriptional level, but cannot rule out the participation of post-transcriptional events in the regulation process throughout ontogenesis.

TL;DR: The population pharmacokinetic–pharmacogenetic model developed in de novo pediatric kidney transplant patients demonstrated that, in children, tacrolimus dosage should be based on weight, hematocrit levels, and CYP3A5 polymorphism.

TL;DR: Musculoskeletal AEs occur due to ciprofloxacin use, however, these musculoskletal events are reversible with management and it is recommended that further prospective controlled studies should be carried out to evaluate the safety of ciproskeletal events, with particular focus on the risk of arthropathy.