M
May Fakhoury
Researcher at French Institute of Health and Medical Research
Publications - 28
Citations - 1230
May Fakhoury is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Population & NONMEM. The author has an hindex of 18, co-authored 28 publications receiving 1113 citations. Previous affiliations of May Fakhoury include Paris Diderot University.
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Journal ArticleDOI
Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients.
Wei Zhao,Valery Elie,Gwenaelle Roussey,Karine Brochard,Patrick Niaudet,V Leroy,Chantal Loirat,Pierre Cochat,Sylvie Cloarec,Jean-Luc André,F. Garaix,Albert Bensman,May Fakhoury,Evelyne Jacqz-Aigrain +13 more
TL;DR: The population pharmacokinetic–pharmacogenetic model developed in de novo pediatric kidney transplant patients demonstrated that, in children, tacrolimus dosage should be based on weight, hematocrit levels, and CYP3A5 polymorphism.
Journal ArticleDOI
Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age.
May Fakhoury,Catherine Litalien,Y Médard,Hélène Cavé,Nadia Ezzahir,Michel Peuchmaur,Evelyne Jacqz-Aigrain +6 more
TL;DR: It is shown that neonates and infants had a significant expression of CYP3A and P-gp mRNA in the intestine, suggesting a different maturation profile of CYp3Aand P- gp with age in the liver and the intestine.
Journal ArticleDOI
Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.
Tiphaine Adam de Beaumais,May Fakhoury,Y Médard,Said Azougagh,Daolun Zhang,Karima Yakouben,Evelyne Jacqz-Aigrain +6 more
TL;DR: Age and both TPMT and ITPA genotypes influenced 6-MP metabolism and high 6-MMPN was associated with hepatotoxicity and should be used to monitor ALL treatment in children.
Journal ArticleDOI
Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring
Wei Zhao,Emmanuel Lopez,Valérie Biran,Xavier Durrmeyer,May Fakhoury,Evelyne Jacqz-Aigrain,Evelyne Jacqz-Aigrain +6 more
TL;DR: An optimised dosing regimen, taking into account birth weight, current weight, postnatal age and serum creatinine, was developed based on a one-compartment pharmacokinetic model and should be used routinely to individualise vancomycin continuous infusion therapy in neonates.
Journal ArticleDOI
External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings
Wei Zhao,Florentia Kaguelidou,Florentia Kaguelidou,Valérie Biran,Daolun Zhang,Karel Allegaert,Edmund V. Capparelli,Nicholas H. G. Holford,Toshimi Kimura,Lo Yl,José Esteban Peris,Alison H. Thomson,Alison H. Thomson,John N. van den Anker,May Fakhoury,Evelyne Jacqz-Aigrain,Evelyne Jacqz-Aigrain +16 more
TL;DR: Differences in predictive performances of models for vancomycin pharmacokinetic models in neonates were found and the importance of analytical techniques for serum creatinine concentrations and vancomYcin as a predictor of van comycin concentrations in Neonates has been confirmed.