E
Ewald A. W. J. Dumont
Researcher at Maastricht University
Publications - 16
Citations - 1310
Ewald A. W. J. Dumont is an academic researcher from Maastricht University. The author has contributed to research in topics: Programmed cell death & Annexin A5. The author has an hindex of 10, co-authored 16 publications receiving 1271 citations.
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Journal ArticleDOI
Visualisation of cell death in vivo in patients with acute myocardial infarction.
Leonard Hofstra,Ing Han Liem,Ewald A. W. J. Dumont,Hendrikus H. Boersma,W.L. van Heerde,Pieter A. Doevendans,E De Muinck,Hein J.J. Wellens,Gerrit J. Kemerink,Chris P. M. Reutelingsperger,Guido A. K. Heidendal +10 more
TL;DR: Increased uptake of Tc-99m-labelled annexin-V is present in the infarct area of patients with an acute myocardial infarction, suggesting that programmed cell death occurs in that area.
Journal ArticleDOI
Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart.
Ewald A. W. J. Dumont,Chris P. M. Reutelingsperger,Jos F.M. Smits,Mat J.A.P. Daemen,Pieter A. Doevendans,Hein J.J. Wellens,Leonard Hofstra +6 more
TL;DR: A novel real-time imaging model to visualize apoptotic membrane changes of single cardiomyocytes in the injured heart of the living mouse, using fluorescent labeled annexin-V to enhance knowledge of intracellular signaling pathways relevant for cell-death regulation and strategies to manipulate these pathways for therapeutic effect is reported.
Journal ArticleDOI
Cardiomyocyte Death Induced by Myocardial Ischemia and Reperfusion: Measurement With Recombinant Human Annexin-V in a Mouse Model
Ewald A. W. J. Dumont,Leonard Hofstra,Waander L. van Heerde,Stephan van den Eijnde,Pieter A. Doevendans,Ebo DeMuinck,Marc A. R. C. Daemen,Jos F.M. Smits,Peter M. Frederik,Hein J.J. Wellens,Mat J.A.P. Daemen,Chris P. M. Reutelingsperger +11 more
TL;DR: The use of labeled human recombinant annexin-V, a protein selectively binding to PS, to detect cardiomyocyte death in an in vivo mouse model of cardiac ischemia and reperfusion (I/R) and the evaluation of cell death–blocking strategies is suggested.
Journal ArticleDOI
Markers of apoptosis in cardiovascular tissues: focus on Annexin V.
W.L. van Heerde,S. Robert-Offerman,Ewald A. W. J. Dumont,Leonard Hofstra,Pieter A. Doevendans,Jos F.M. Smits,Mat J.A.P. Daemen,Chris P. M. Reutelingsperger +7 more
TL;DR: The principle, characteristics, pro's and contra's of this new apoptosis detection assay will be discussed, and the advantages and limitations of these techniques for their use in cardiovascular research will be outlined.
Journal ArticleDOI
Annexin A5 Uptake in Ischemic Myocardium: Demonstration of Reversible Phosphatidylserine Externalization and Feasibility of Radionuclide Imaging
Heidi Kenis,Harmen Reinier Zandbergen,Leonard Hofstra,Artiom Petrov,Ewald A. W. J. Dumont,Francis Blankenberg,Neena B. Haider,Nicole Bitsch,Marion J.J. Gijbels,Johan W. Verjans,Navneet Narula,Jagat Narula,Chris P. M. Reutelingsperger +12 more
TL;DR: Phosphatidylserine exposure after ischemia in the rabbit heart could be detected by radionuclide imaging with 99mTc-AA5, indicating the reversibility of the apoptotic process.