M
Mat J.A.P. Daemen
Researcher at University of Amsterdam
Publications - 166
Citations - 14683
Mat J.A.P. Daemen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Inflammation & Endothelial stem cell. The author has an hindex of 62, co-authored 160 publications receiving 13139 citations. Previous affiliations of Mat J.A.P. Daemen include Utrecht University & Maastricht University.
Papers
More filters
Journal ArticleDOI
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Stephane Heymans,Aernout Luttun,Dieter Nuyens,Gregor Theilmeier,Esther E. Creemers,Lieve Moons,G D Dyspersin,Jack P.M. Cleutjens,M Shipley,A Angellilo,Marcel Levi,O Nübe,Andrew Baker,Eli Keshet,Florea Lupu,Jean-Marc Herbert,Jos F.M. Smits,Steven D. Shapiro,Myriam Baes,Marcel Borgers,Desire Collen,Mat J.A.P. Daemen,Peter Carmeliet +22 more
TL;DR: Temporary administration of PA inhibitor-1 or the matrix metalloproteinase-inhibitor TIMP-1 completely protected wild-type mice against rupture but did not abort infarct healing, thus constituting a new approach to prevent cardiac rupture after acute myocardial infarction.
Journal ArticleDOI
Angiotensin ii induces smooth muscle cell proliferation in the normal and injured rat arterial wall
TL;DR: The present study explored the possibility that neointimal smooth muscle cells, the characteristic cells of restenosis and atherosclerosis, are selectively stimulated to replicate by a hypertensive stimulus and significantly increased DNA synthesis in the media of the carotid artery.
Journal ArticleDOI
Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques
C.R. Dhore,Jack P.M. Cleutjens,Esther Lutgens,Kitty B.J.M. Cleutjens,Piet Geusens,Peter J.E.H.M. Kitslaar,Jan H.M. Tordoir,Henri M. H. Spronk,Cees Vermeer,Mat J.A.P. Daemen +9 more
TL;DR: The observed expression patterns suggest a tight regulation of the expression of bone matrix regulatory proteins during human atherogenesis, which might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification.
Journal ArticleDOI
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Jan Borén,M. John Chapman,M. John Chapman,Ronald M. Krauss,Chris J. Packard,Jacob F. Bentzon,Jacob F. Bentzon,Christoph J. Binder,Mat J.A.P. Daemen,Linda L. Demer,Robert A. Hegele,Stephen J. Nicholls,Børge G. Nordestgaard,Gerald F. Watts,Gerald F. Watts,Eric Bruckert,Sergio Fazio,Brian A. Ference,Brian A. Ference,Ian D. Graham,Jay D. Horton,Ulf Landmesser,Ulrich Laufs,Luis Masana,Gerard Pasterkamp,Frederick J. Raal,Kausik K. Ray,Heribert Schunkert,Marja-Riitta Taskinen,Bart van de Sluis,Olov Wiklund,Lale Tokgozoglu,Alberico L. Catapano,Henry N. Ginsberg +33 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Journal ArticleDOI
Matrix Metalloproteinase Inhibition After Myocardial Infarction A New Approach to Prevent Heart Failure
TL;DR: The biology of MMPs is described and the central role of the plasminogen system as an important activator of M MPs in the remodeling process after myocardial infarction is speculated on.