H
Hendrikus H. Boersma
Researcher at University Medical Center Groningen
Publications - 84
Citations - 2571
Hendrikus H. Boersma is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Myocardial infarction & Positron emission tomography. The author has an hindex of 26, co-authored 79 publications receiving 2228 citations. Previous affiliations of Hendrikus H. Boersma include Maastricht University & University of Groningen.
Papers
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Journal ArticleDOI
Visualisation of cell death in vivo in patients with acute myocardial infarction.
Leonard Hofstra,Ing Han Liem,Ewald A. W. J. Dumont,Hendrikus H. Boersma,W.L. van Heerde,Pieter A. Doevendans,E De Muinck,Hein J.J. Wellens,Gerrit J. Kemerink,Chris P. M. Reutelingsperger,Guido A. K. Heidendal +10 more
TL;DR: Increased uptake of Tc-99m-labelled annexin-V is present in the infarct area of patients with an acute myocardial infarction, suggesting that programmed cell death occurs in that area.
Journal Article
Past, Present, and Future of Annexin A5: From Protein Discovery to Clinical Applications*
Hendrikus H. Boersma,Bas L.J.H. Kietselaer,Leo M L Stolk,Abdelkader Bennaghmouch,Leonard Hofstra,Jagat Narula,Guido A. K. Heidendal,Chris P. M. Reutelingsperger +7 more
TL;DR: The clinical relevance, limitations, and future perspectives of this approach of visualizing cell death are discussed in this article, as are other potential applications of anxA5.
Journal ArticleDOI
2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis.
Nobuhiro Tahara,Jogeshwar Mukherjee,Hans J. de Haas,Artiom Petrov,Ahmed Tawakol,Neena B. Haider,Atsuko Tahara,Cristian Constantinescu,Jun Zhou,Hendrikus H. Boersma,Tsutomu Imaizumi,Masataka Nakano,Aloke V. Finn,Zahi A. Fayad,Renu Virmani,Valentin Fuster,Lisardo Boscá,Jagat Narula +17 more
TL;DR: It is demonstrated that FDM restricts binding of anti–mannose receptor antibody to macrophages by approximately 35% and that mannose receptor targeting may provide an additional avenue for imaging of plaque inflammation.
Journal Article
In Vivo Detection of Cell Death in the Area at Risk in Acute Myocardial Infarction
Paul W. L. Thimister,Leonard Hofstra,Ing Han Liem,Hendrikus H. Boersma,Gerrit J. Kemerink,Chris P. M. Reutelingsperger,Guido A. K. Heidendal +6 more
TL;DR: In acute MI, an increase of programmed cell death can be correctly localized in vivo in the area at risk and the decrease in (99m)Tc-sestamibi defect size in the subacute phase of the MI further suggests that in parts of the Area at risk, reversible myocardial damage rather than necrosis is present in cardiomyocytes.
Journal ArticleDOI
Photoresponsive molecular tools for emerging applications of light in medicine.
Ilse M. Welleman,Ilse M. Welleman,Mark W. H. Hoorens,Mark W. H. Hoorens,Ben L. Feringa,Hendrikus H. Boersma,Wiktor Szymanski,Wiktor Szymanski +7 more
TL;DR: This work describes the applications scenarios that can be envisioned in clinical practice and uses those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology.