E
Eycke Böhme
Researcher at Free University of Berlin
Publications - 41
Citations - 4883
Eycke Böhme is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Soluble guanylyl cyclase & Nitric oxide. The author has an hindex of 26, co-authored 41 publications receiving 4839 citations. Previous affiliations of Eycke Böhme include University of Freiburg & Heidelberg University.
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Journal ArticleDOI
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
TL;DR: According to these results, activation of brain NO synthase by Ca2+ at subphysiological levels of intracellular L-arginine or H4biopterin may result in the formation of reactive oxygen species instead of NO, and N omega-nitro-substituted L- arginine analogues represent useful tools to effectively block No synthase-catalysed oxygen activation.
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Purification of a Ca2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin.
Bernd Mayer,M. John,Eycke Böhme +2 more
TL;DR: Two NO synthase isoenzymes are postulated: a cytokine‐inducible enzyme in macrophages and a constitutive, Ca2+‐regulated enzyme in various other cells.
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Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase
Bernd Mayer,M. John,Burghard Heinzel,Ernst R. Werner,Helmut Wachter,Günter Schultz,Eycke Böhme +6 more
TL;DR: It is found that purified NO synthase contains enzyme‐bound H4 biopterin, explaining the enzymatic activity observed in the absence of added cofactor, and these results indicate that No synthase essentially depends on H4Biopterin as a cofactor which is recycled during enzymatically NO formation.
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Arginine is a physiological precursor of endothelium-derived nitric oxide
Harald H.H.W. Schmidt,Heinz Nau,Werner Wittfoht,Jörg C. Gerlach,Karl-Ernst Prescher,Marcus M. Klein,Feraydoon Niroomand,Eycke Böhme +7 more
TL;DR: It is concluded that the terminal guanidino nitrogens of L-arginine are the physiological precursors of endothelium-derived NO.
Journal ArticleDOI
Soluble guanylate cyclase purified from bovine lung contains heme and copper
TL;DR: Purification of soluble guanylate cyclase from bovine lung can be achieved without major loss in stimulation by sodium nitropmsside and related agents, and a chromophore is a heine, which has been identified as ferroprotoporphyrin IX and copper was detected in the purified preparations.