Bernd Mayer

TL;DR: ODQ is the first inhibitor that acts selectively at the level of a physiological NO "receptor" and, as such, is likely to prove useful for investigating the function of the cGMP pathway in NO signal transduction.

TL;DR: The pteridine tetrahydrobiopterin (BH4) is a key feature of NOS, affecting dimerisation and electron transfer, although its full role in catalysis remains to be determined.

TL;DR: Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death.

TL;DR: Progress in NO chemistry and the enzymology of NO synthases is discussed, and its actions in the cardiovascular, nervous and immune systems are explained.

TL;DR: According to these results, activation of brain NO synthase by Ca2+ at subphysiological levels of intracellular L-arginine or H4biopterin may result in the formation of reactive oxygen species instead of NO, and N omega-nitro-substituted L- arginine analogues represent useful tools to effectively block No synthase-catalysed oxygen activation.