A
Anne Jones
Researcher at National Institutes of Health
Publications - 18
Citations - 2361
Anne Jones is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Proinflammatory cytokine & Vasculitis. The author has an hindex of 11, co-authored 17 publications receiving 1433 citations.
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Journal ArticleDOI
Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2
Qing Zhou,Dan Yang,Amanda K. Ombrello,Andrey Zavialov,Camilo Toro,Anton V. Zavialov,Deborah L. Stone,Jae Jin Chae,Sergio D. Rosenzweig,Kevin Bishop,Karyl S. Barron,Hye Sun Kuehn,Patrycja Hoffmann,Alejandra Negro,Wanxia L. Tsai,Edward W. Cowen,Wuhong Pei,Joshua D. Milner,Christopher Silvin,Theo Heller,David T. Chin,Nicholas J. Patronas,John S. Barber,Chyi-Chia Richard Lee,Geryl Wood,Alexander Ling,Susan J. Kelly,David E. Kleiner,James C. Mullikin,Nancy J. Ganson,Heidi H. Kong,Sophie Hambleton,Fabio Candotti,Martha Quezado,Katherine R. Calvo,Hawwa Alao,Beverly K. Barham,Anne Jones,James F. Meschia,Bradford B. Worrall,Scott E. Kasner,Stephen S. Rich,Raphaela Goldbach-Mansky,Mario Abinun,Elizabeth Chalom,Alisa Gotte,Marilynn Punaro,Virginia Pascual,James W. Verbsky,Troy R. Torgerson,Nora G. Singer,Timothy R. Gershon,Seza Ozen,Omer Karadag,Thomas A. Fleisher,Elaine F. Remmers,Shawn M. Burgess,Susan Moir,Massimo Gadina,Raman Sood,Michael S. Hershfield,Manfred Boehm,Daniel L. Kastner,Ivona Aksentijevich +63 more
TL;DR: Loss-of-function mutations in CECR1 were associated with a spectrum of vascular and inflammatory phenotypes, ranging from early-onset recurrent stroke to systemic vasculopathy or vasculitis, and were prevented by coinjection with nonmutated (but not with mutated) human C ECR1.
Journal ArticleDOI
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Qing Zhou,Hongying Wang,Daniella M. Schwartz,Monique Stoffels,Yong Hwan Park,Yuan Zhang,Dan Yang,Erkan Demirkaya,Masaki Takeuchi,Wanxia Li Tsai,Jonathan J. Lyons,Xiaomin Yu,Claudia Ouyang,Celeste Chen,David T. Chin,Kristien J. M. Zaal,Settara C. Chandrasekharappa,Eric P. Hanson,Zhen Yu,James C. Mullikin,Sarfaraz Hasni,Ingrid E. Wertz,Amanda K. Ombrello,Deborah L. Stone,Patrycja Hoffmann,Anne Jones,Beverly K. Barham,Helen L. Leavis,Annet Van Royen-Kerkof,Cailin H. Sibley,Ezgi Deniz Batu,Ahmet Gül,Richard M. Siegel,Manfred Boehm,Joshua D. Milner,Seza Ozen,Massimo Gadina,Jae Jin Chae,Ronald M. Laxer,Daniel L. Kastner,Ivona Aksentijevich +40 more
TL;DR: A new disease caused by high-penetrance heterozygous germline mutations in TNFAIP3, which encodes the NF-κB regulatory protein A20, in six unrelated families with early-onset systemic inflammation is described, which resembles Behçet's disease.
Journal ArticleDOI
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
David B. Beck,Marcela A. Ferrada,Keith A. Sikora,Amanda K. Ombrello,Jason C. Collins,Wuhong Pei,Nicholas Balanda,Daron L. Ross,Daniela Ospina Cardona,Zhijie Wu,Bhavisha A Patel,Kalpana Manthiram,Emma M. Groarke,Fernanda Gutierrez-Rodrigues,Patrycja Hoffmann,Sofia Rosenzweig,Shuichiro Nakabo,Laura W. Dillon,Christopher S. Hourigan,Wanxia L. Tsai,Sarthak Gupta,Carmelo Carmona-Rivera,Anthony J. Asmar,Lisha Xu,Hirotsugu Oda,Wendy Goodspeed,Karyl S. Barron,Michele Nehrebecky,Anne Jones,Ryan S. Laird,Natalie Deuitch,Dorota Rowczenio,Emily Rominger,Kristina V. Wells,Chyi-Chia Richard Lee,Weixin Wang,Megan Trick,James C. Mullikin,Gustaf Wigerblad,Stephen R. Brooks,Stefania Dell'Orso,Zuoming Deng,Jae Jin Chae,Alina Dulau-Florea,May Christine V. Malicdan,Danica Novacic,Robert A. Colbert,Mariana J. Kaplan,Massimo Gadina,Sinisa Savic,Helen J. Lachmann,Mones Abu-Asab,Benjamin D. Solomon,Kyle Retterer,William A. Gahl,Shawn M. Burgess,Ivona Aksentijevich,Neal S. Young,Katherine R. Calvo,Achim Werner,Daniel L. Kastner,Peter C. Grayson +61 more
TL;DR: Using a genotype-driven approach, this disorder is identified that connects seemingly unrelated adult-onset inflammatory syndromes and is named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Journal ArticleDOI
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade
Silvia Stojanov,Sivia K. Lapidus,Puja Chitkara,Henry M. Feder,Juan C. Salazar,Thomas A. Fleisher,Margaret R. Brown,Kathryn M. Edwards,Michael M. Ward,Robert A. Colbert,Hong-Wei Sun,Geryl Wood,Beverly K. Barham,Anne Jones,Ivona Aksentijevich,Raphaela Goldbach-Mansky,Balu Athreya,Karyl S. Barron,Daniel L. Kastner +18 more
TL;DR: The data suggest an environmentally triggered activation of complement and IL-1β/-18 during PFAPA flares, with induction of Th1-chemokines and subsequent retention of activated T cells in peripheral tissues, may be beneficial for treatment ofPFAPA attacks.
Journal ArticleDOI
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Najoua Lalaoui,Najoua Lalaoui,Steven E. Boyden,Hirotsugu Oda,Geryl Wood,Deborah L. Stone,Diep Chau,Lin Liu,Lin Liu,Monique Stoffels,Tobias Kratina,Kate E. Lawlor,Kate E. Lawlor,Kristien J. M. Zaal,Patrycja Hoffmann,Nima Etemadi,Nima Etemadi,Kristy Shield-Artin,Kristy Shield-Artin,Christine Biben,Christine Biben,Wanxia Li Tsai,Mary Blake,Hye Sun Kuehn,Dan Yang,Holly Anderton,Holly Anderton,Natasha Silke,Laurens Wachsmuth,Lixin Zheng,Natalia Sampaio Moura,David B. Beck,Gustavo Gutierrez-Cruz,Amanda K. Ombrello,Gineth Pinto-Patarroyo,Andrew J. Kueh,Andrew J. Kueh,Marco J Herold,Marco J Herold,Cathrine Hall,Hongying Wang,Jae Jin Chae,Natalia I. Dmitrieva,Mark D. McKenzie,Mark D. McKenzie,Amanda Light,Beverly K. Barham,Anne Jones,Tina Romeo,Qing Zhou,Ivona Aksentijevich,James C. Mullikin,Andrew J. Gross,Anthony K. Shum,Edwin D. Hawkins,Edwin D. Hawkins,Seth L. Masters,Seth L. Masters,Michael J. Lenardo,Manfred Boehm,Sergio D. Rosenzweig,Manolis Pasparakis,Anne K. Voss,Anne K. Voss,Massimo Gadina,Daniel L. Kastner,John Silke,John Silke +67 more
TL;DR: It is shown that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life, and a cleavage-resistant Ripk1 D325A mutant mouse strain generated limits TNF-induced cell death and inflammation.