F
F. Patrick Ross
Researcher at Hospital for Special Surgery
Publications - 124
Citations - 14978
F. Patrick Ross is an academic researcher from Hospital for Special Surgery. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 52, co-authored 121 publications receiving 14005 citations. Previous affiliations of F. Patrick Ross include Cornell University & Washington University in St. Louis.
Papers
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Journal ArticleDOI
Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
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TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
Jonathan Lam,Sunao Takeshita,Jane E. Barker,Osami Kanagawa,F. Patrick Ross,Steven L. Teitelbaum +5 more
TL;DR: While TNF-alpha alone does not induce osteoclastogenesis, it does so both in vitro and in vivo by directly targeting macrophages within a stromal environment that expresses permissive levels of RANKL, indicating a more convenient target in arresting inflammatory osteolysis.
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β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
Kairbaan Hodivala-Dilke,Kevin P. McHugh,Dimitrios A. Tsakiris,Helen Rayburn,Denise Crowley,Mollie Ullman-Cullere,F. Patrick Ross,Barry S. Coller,Steven L. Teitelbaum,Richard O. Hynes +9 more
TL;DR: It is reported that postnatal neovascularization of the retina appears to be beta3-integrin-independent, contrary to expectations from inhibition experiments.
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Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
Kevin P. McHugh,Kairbaan Hodivala-Dilke,Minghao Zheng,Noriyuki Namba,Jonathan Lam,Deborah V. Novack,Xu Feng,F. Patrick Ross,Richard O. Hynes,Steven L. Teitelbaum +9 more
TL;DR: It is established that although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteOClast function.
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IL-1 mediates TNF-induced osteoclastogenesis
TL;DR: IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclass precursors under the aegis of p38 MAPK.