K
Kevin P. McHugh
Researcher at Beth Israel Deaconess Medical Center
Publications - 30
Citations - 3333
Kevin P. McHugh is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Osteoclast & Cellular differentiation. The author has an hindex of 21, co-authored 30 publications receiving 3217 citations. Previous affiliations of Kevin P. McHugh include Joint Institute for Nuclear Research & Washington University in St. Louis.
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Journal ArticleDOI
β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
Kairbaan Hodivala-Dilke,Kevin P. McHugh,Dimitrios A. Tsakiris,Helen Rayburn,Denise Crowley,Mollie Ullman-Cullere,F. Patrick Ross,Barry S. Coller,Steven L. Teitelbaum,Richard O. Hynes +9 more
TL;DR: It is reported that postnatal neovascularization of the retina appears to be beta3-integrin-independent, contrary to expectations from inhibition experiments.
Journal ArticleDOI
Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
Kevin P. McHugh,Kairbaan Hodivala-Dilke,Minghao Zheng,Noriyuki Namba,Jonathan Lam,Deborah V. Novack,Xu Feng,F. Patrick Ross,Richard O. Hynes,Steven L. Teitelbaum +9 more
TL;DR: It is established that although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteOClast function.
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Tumor Necrosis Factor-α Mediates Orthopedic Implant Osteolysis
Kurt Merkel,Jeanne M. Erdmann,Kevin P. McHugh,Yousef Abu-Amer,F. Patrick Ross,Steven L. Teitelbaum +5 more
TL;DR: Failure of BMMs derived from mice deleted of both the p55 and p75 TNF receptors to express c-src in response to polymemthylmethacrylate indicates TNF is an essential mediator of particle induction of this osteoclast specific protein.
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NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation
Tania N. Crotti,Merrilee R. Flannery,Merrilee R. Flannery,Nicole C. Walsh,Nicole C. Walsh,Joseph D. Fleming,Steven R. Goldring,Steven R. Goldring,Steven R. Goldring,Kevin P. McHugh,Kevin P. McHugh,Kevin P. McHugh +11 more
TL;DR: The beta3 gene is established as a direct target of NFATc1 in RANKL-dependent osteoclast formation using the calcineurin pathway inhibitory peptide 11R-VIVIT and involved in regulating the human beta3 integrin promoter.
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Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-γ in Human Osteoclast Precursors
Jong Dae Ji,Kyung-Hyun Park-Min,Zenxin Shen,Roberto J. Fajardo,Steven R. Goldring,Steven R. Goldring,Kevin P. McHugh,Lionel B. Ivashkiv,Lionel B. Ivashkiv +8 more
TL;DR: A new mechanism of homeostatic regulation of osteoclastogenesis that targets RANK expression and limits bone resorption during infection and inflammation is identified.