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Xu Feng
Researcher at University of Alabama at Birmingham
Publications - 97
Citations - 6687
Xu Feng is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 39, co-authored 88 publications receiving 5972 citations. Previous affiliations of Xu Feng include Shanghai University & Cedars-Sinai Medical Center.
Papers
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Journal ArticleDOI
TGF-Β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
Yi Tang,Xiangwei Wu,Xiangwei Wu,Xiangwei Wu,Weiqi Lei,Lijuan Pang,Lijuan Pang,Chao Wan,Zhenqi Shi,Ling Zhao,Tim R. Nagy,Xinyu Peng,Junbo Hu,Xu Feng,Wim Van Hul,Mei Wan,Xu Cao +16 more
TL;DR: It is shown using in vitro and in vivo models that active TGF-β1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to theBone resorptive sites and that this process is mediated through a SMAD signaling pathway.
Journal ArticleDOI
Disorders of Bone Remodeling
Xu Feng,Jay M. McDonald +1 more
TL;DR: The major diseases of bone remodeling are reviewed, emphasizing the current understanding of the underlying pathophysiological mechanisms.
Journal ArticleDOI
Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
Kevin P. McHugh,Kairbaan Hodivala-Dilke,Minghao Zheng,Noriyuki Namba,Jonathan Lam,Deborah V. Novack,Xu Feng,F. Patrick Ross,Richard O. Hynes,Steven L. Teitelbaum +9 more
TL;DR: It is established that although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteOClast function.
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Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators
Taixing Cui,Francisco J. Schopfer,Jifeng Zhang,Kai Chen,Tomonaga Ichikawa,Paul R. S. Baker,Carlos Batthyány,Balu K. Chacko,Xu Feng,Rakesh P. Patel,Anupam Agarwal,Bruce A. Freeman,Yuqing E. Chen +12 more
TL;DR: Observations indicate that nitroalkenes such as LNO2 and OA-NO2, derived from reactions of unsaturated fatty acids and oxides of nitrogen, are a class of endogenous anti-inflammatory mediators.
Journal ArticleDOI
RANKing intracellular signaling in osteoclasts.
TL;DR: This review is focused on discussing the current understanding of RANK signaling and signaling crosstalk between RANK and the various factors in osteoclasts.