F
Fadi Sheban
Researcher at Weizmann Institute of Science
Publications - 5
Citations - 543
Fadi Sheban is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 2, co-authored 2 publications receiving 210 citations.
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Journal ArticleDOI
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program
Laufey Geirsdottir,Eyal David,Hadas Keren-Shaul,Assaf Weiner,Stefan Cornelius Bohlen,Jana Neuber,Adam Balic,Amir Giladi,Fadi Sheban,Charles-Antoine Dutertre,Christine Pfeifle,Francesca Peri,Antonella Raffo-Romero,Jacopo Vizioli,Kaspar Matiasek,Christian Scheiwe,Stephan Meckel,Kerstin Mätz-Rensing,Franziska van der Meer,Finnbogi Rutur Thormodsson,Christine Stadelmann,Noga Zilkha,Tali Kimchi,Florent Ginhoux,Igor Ulitsky,Daniel Erny,Ido Amit,Marco Prinz +27 more
TL;DR: This study finds that microglia express a conserved core gene program of orthologous genes from rodents to humans, including ligands and receptors associated with interactions between glia and neurons, which provides an essential resource of conserved and divergent microglian pathways across evolution.
Journal ArticleDOI
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Yonatan Katzenelenbogen,Fadi Sheban,Adam Yalin,Ido Yofe,Dmitry Svetlichnyy,Diego Jaitin,Chamutal Bornstein,Adi Moshe,Hadas Keren-Shaul,Merav Cohen,Shuang-Yin Wang,Baoguo Li,Eyal David,Tomer-Meir Salame,Assaf Weiner,Ido Amit +15 more
TL;DR: This study establishes INs-seq as a broadly applicable technology for elucidating integrated transcriptional and intra-cellular maps and identifies the molecular signature of myeloid suppressive cells in tumors.
Journal ArticleDOI
LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma
Chamutal Gur,Shuang-Yin Wang,Fadi Sheban,Mor Zada,Baoguo Li,Fadi Kharouf,H Peleg,Suhail Aamar,Adam Yalin,Daniel Kirschenbaum,Yolanda Braun-Moscovici,Diego Jaitin,Tomer meir-salame,Efrat Hagai,Bjørt K Kragesteen,Batia Avni,Sigal Grisariu,Chamutal Bornstein,Shir Shlomi-Loubaton,Eyal David,Rony Shreberk-Hassidim,Vered Molho-Pessach,Dalit Amar,Tomer Tzur,Rottem Kuint,Moshe Gross,Oren Barboy,Adi Moshe,Liat Fellus-Alyagor,Dana Hirsch,Yoseph Addadi,Shlomit Erenfeld,Moshe Biton,Tehila Tzemach,Anat Scheiman Elazary,Yaakov Naparstek,R. Tzemach,Assaf Weiner,Amir Giladi,Alexandra Balbir-Gurman,Ido Amit +40 more
TL;DR: In this paper , a population-scale single-cell genomic analysis of skin and blood samples of 56 healthy controls and 97 systemic sclerosis patients at different stages of the disease was conducted, which revealed ScAF-specific markers, pathways, regulatory elements, and transcription factors underlining disease development.
Journal ArticleDOI
The transcriptional and regulatory identity of erythropoietin producing cells
Bjørt K Kragesteen,Amir Giladi,Eyal David,Shahar Halevi,Laufey Geirsdottir,Baoguo Li,Andreas M. Bapst,K. Z. Xie,Yonatan Katzenelenbogen,Sophie L. Dahl,Fadi Sheban,Anna Gurevich-Shapiro,Mor Zada,Truong San Phan,Roberto Avellino,Shuang-Yin Wang,Oren Barboy,Shir Shlomi-Loubaton,Sandra Winning,Philipp Markwerth,Snir Dekalo,Hadas Keren-Shaul,Merav Kedmi,Martin Sikora,Joachim Fandrey,Thorfinn Sand Korneliussen,Josef T. Prchal,Barak Rosenzweig,Vladimir Yutkin,Fernando Racimo,Eske Willerslev,Chamutal Gur,Roland H. Wenger,Ido Amit +33 more
Journal ArticleDOI
It takes two to tango: the role of tumor-associated macrophages in T cell-directed immune checkpoint blockade therapy
TL;DR: In this paper , the authors discuss the role of TAMs in the success of T cell-directed immune checkpoint blockade therapies, as well as the present, and the future of clinical trials on combinatorial therapies targeting both cell types.