F
Fang Cheng
Researcher at Lund University
Publications - 44
Citations - 1669
Fang Cheng is an academic researcher from Lund University. The author has contributed to research in topics: Heparan sulfate & Glypican-1. The author has an hindex of 21, co-authored 39 publications receiving 1558 citations. Previous affiliations of Fang Cheng include VU University Amsterdam.
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Journal ArticleDOI
The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis
Staffan Sandgren,Anders Wittrup,Fang Cheng,Mats Jönsson,Erik A. Eklund,Susann Busch,Mattias Belting +6 more
TL;DR: It is concluded that the human antimicrobial peptide LL-37 binds to, protects, and efficiently targets DNA plasmid to the nuclei of mammalian cells through caveolae-independent membrane raft endocytosis and cell surface proteoglycans.
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Nuclear Targeting of Macromolecular Polyanions by an HIV-Tat Derived Peptide ROLE FOR CELL-SURFACE PROTEOGLYCANS
TL;DR: In this article, the authors studied cellular uptake of macromolecular polyanions, i.e. DNA and glycosaminoglycans, and a polybasic HIV-Tat derived peptide (GRKKRRQRRRPPQC) using fluorescence assisted cell sorting and confocal fluorescence microscopy.
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Glypican-1 Is a Vehicle for Polyamine Uptake in Mammalian Cells A PIVOTAL ROLE FOR NITROSOTHIOL-DERIVED NITRIC OXIDE
Mattias Belting,Katrin Mani,Mats Jönsson,Fang Cheng,Staffan Sandgren,Susanne Jonsson,Kan Ding,Jean-Guy Delcros,Lars-Åke Fransson +8 more
TL;DR: It is demonstrated that inhibition of Gpc-1 expression abrogates spermine uptake and intracellular delivery using RNA interference technology as well as biochemical and microscopic techniques applied to both normal and uptake-deficient cells.
Journal ArticleDOI
Novel aspects of glypican glycobiology.
TL;DR: Glypicans are involved in growth factor signalling and transport, e.g. of polyamines, and how glypican and its degradation products and the cargo exit from the recycling route is an enigma.
Journal ArticleDOI
Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues.
Fang Cheng,Dick Heinegård,Anders Malmström,Artur Schmidtchen,Keiichi Yoshida,Lars-AÅke Fransson +5 more
TL;DR: Tissue-specific, periodic and wave-like patterns of distribution for the two epimeric uronic acids, as well as specific patterns of sulphation in dermatan sulphates derived from either decorin or biglycan are demonstrated.