F
Faruk Sheikh
Researcher at Center for Drug Evaluation and Research
Publications - 28
Citations - 4385
Faruk Sheikh is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Cytokine & Gene. The author has an hindex of 20, co-authored 27 publications receiving 4009 citations. Previous affiliations of Faruk Sheikh include Center for Biologics Evaluation and Research.
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Journal ArticleDOI
Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling.
Harold Dickensheets,N Vazquez,Faruk Sheikh,Sebastien Gingras,Peter J. Murray,John J. Ryan,Raymond P. Donnelly +6 more
TL;DR: It is found that IL-4, like IFN-γ, induces rapid de novo expression of SOCS-1 in primary macrophages and SOCs-1 feedback inhibits expression of STAT6-responsive genes.
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An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
TL;DR: Findings demonstrate that induction of ISGF3 activity and ISG expression by LPS is critically dependent on intermediate production of IFN‐β and autocrine signaling through type I IFN receptors.
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Leishmania donovani-Induced Expression of Suppressor of Cytokine Signaling 3 in Human Macrophages: a Novel Mechanism for Intracellular Parasite Suppression of Activation
Sylvie Bertholet,Harold Dickensheets,Faruk Sheikh,Albert A. Gam,Raymond P. Donnelly,Richard T. Kenney +5 more
TL;DR: The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response.
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IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling
Adeola Obajemu,Nina Rao,Kari A. Dilley,Joselin M. Vargas,Faruk Sheikh,Raymond P. Donnelly,Reed S. Shabman,Eric G. Meissner,Ludmila Prokunina-Olsson,Olusegun O. Onabajo +9 more
TL;DR: This study used fresh primary human hepatocytes treated with recombinant type III IFNs or infected with Sendai virus to model acute viral infection and validated the findings in HepG2 cell line models.
Journal ArticleDOI
Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells.
Anita Kohli,Xiaozhen Zhang,Jun Yang,Rodney S. Russell,Raymond P. Donnelly,Faruk Sheikh,Amy C. Sherman,Howard A. Young,Tom Imamichi,Richard A. Lempicki,Henry Masur,Shyam Kottilil +11 more
TL;DR: The findings from the comparative analysis of IFN‐α andIFN‐λ in HCV‐infected and noninfected cells support the clinical use of IFn‐λ as a potential alternative to IFN •α in the treatment of chronic hepatitis C.