S
Shyam Kottilil
Researcher at University of Maryland, Baltimore
Publications - 254
Citations - 10353
Shyam Kottilil is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Hepatitis C virus & Hepatitis C. The author has an hindex of 42, co-authored 217 publications receiving 9039 citations. Previous affiliations of Shyam Kottilil include National Institutes of Health & University of Maryland, College Park.
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Journal ArticleDOI
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
Susan Moir,Jason Ho,Angela Malaspina,Wei-wei Wang,Angela C. DiPoto,Marie A. O'Shea,Gregg Roby,Shyam Kottilil,James Arthos,Michael A. Proschan,Tae-Wook Chun,Anthony S. Fauci +11 more
TL;DR: HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals, and strikingly, HIV- specific responses were enriched in these exhausted tissuelike memory B cells, whereas total immunoglobulin and influenza-specific responses were enrichment in classical memory B Cells.
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Infections Caused by Scedosporium spp.
Karoll J. Cortez,Emmanuel Roilides,Flavio Quiroz-Telles,Joseph Meletiadis,Charalampos Antachopoulos,Tena A. Knudsen,Wendy Buchanan,Jeffrey Milanovich,Deanna A. Sutton,Annette W. Fothergill,Michael G. Rinaldi,Yvonne R. Shea,Theoklis E. Zaoutis,Shyam Kottilil,Thomas J. Walsh +14 more
TL;DR: Scedosporium spp.
Journal ArticleDOI
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
James Arthos,Claudia Cicala,Elena Martinelli,Elena Martinelli,Katilyn Macleod,Donald Van Ryk,Danlan Wei,Zhen Xiao,Timothy D. Veenstra,Thomas P Conrad,Richard A. Lempicki,Sherry McLaughlin,Massimiliano Pascuccio,Ravindra Gopaul,Jonathan P. McNally,Catherine C. Cruz,Nina Censoplano,Eva Chung,Kristin N. Reitano,Shyam Kottilil,Diana J. Goode,Anthony S. Fauci +21 more
TL;DR: It is demonstrated here that the HIV-1 envelope protein gp120 bound to an activated form of α4β7, a peptide motif that mimics structures presented by the natural ligands of α 4β7 in the V2 loop of gp120.
Journal ArticleDOI
Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy
Tae Wook Chun,David C. Nickle,Jesse S. Justement,Jennifer Hartt Meyers,Gregg Roby,Claire W. Hallahan,Shyam Kottilil,Susan Moir,JoAnn M. Mican,James I. Mullins,Douglas J. Ward,Joseph A. Kovacs,Peter J. Mannon,Anthony S. Fauci +13 more
TL;DR: It is suggested that the GALT may play a major role in the persistence of HIV in such individuals who had been receiving effective antiviral therapy for prolonged periods of time, and a possible mechanism for the maintenance of viral reservoirs revolving around the Galt of HIV-infected individuals despite long-term viral suppression is provided.
Journal Article
Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy. Commentary
Steven A. Yukl,Joseph K. Wong,Tae-Wook Chun,David C. Nickle,Jesse S. Justement,Jennifer Hartt Meyers,Gregg Roby,Claire W. Hallahan,Shyam Kottilil,Susan Moir,JoAnn M. Mican,James I. Mullins,Douglas J. Ward,Joseph A. Kovacs,Peter J. Mannon,Anthony S. Fauci +15 more
TL;DR: In this article, the authors found incomplete recoveries of CD4 + T cells in the GALT of aviremic, HIV-infected individuals who had received up to 9.9 years of effective antiretroviral therapy.