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Fatema Abdurrob
Researcher at Picower Institute for Learning and Memory
Publications - 9
Citations - 1819
Fatema Abdurrob is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Induced pluripotent stem cell & Biology. The author has an hindex of 5, co-authored 7 publications receiving 1132 citations. Previous affiliations of Fatema Abdurrob include Massachusetts Institute of Technology.
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Journal ArticleDOI
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Hannah Iaccarino,Annabelle C. Singer,Anthony J Martorell,Anthony J Martorell,Andrii Rudenko,Andrii Rudenko,Fan Gao,Fan Gao,Tyler Z. Gillingham,Tyler Z. Gillingham,Hansruedi Mathys,Hansruedi Mathys,Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,Oleg Kritskiy,Fatema Abdurrob,Fatema Abdurrob,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Rebecca G. Canter,Rebecca G. Canter,Richard Rueda,Richard Rueda,Emery N. Brown,Edward S. Boyden,Edward S. Boyden,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +29 more
TL;DR: Reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.
Journal ArticleDOI
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Yuan-Ta Lin,Jinsoo Seo,Jinsoo Seo,Fan Gao,Heather M. Feldman,Hsin-Lan Wen,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Elizabeta Gjoneska,Elizabeta Gjoneska,Waseem K. Raja,Waseem K. Raja,Jemmie Cheng,Jemmie Cheng,Richard Rueda,Oleg Kritskiy,Fatema Abdurrob,Zhuyu Peng,Blerta Milo,Chung Jong Yu,Sara Elmsaouri,Dilip Dey,Tak Ko,Bruce A. Yankner,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.
Journal ArticleDOI
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes
Waseem K. Raja,Alison E. Mungenast,Yuan-Ta Lin,Tak Ko,Fatema Abdurrob,Jinsoo Seo,Li-Huei Tsai +6 more
TL;DR: It is found that treatment of patient-derived organoids with β- and γ-secretase inhibitors significantly reduces amyloid and tau pathology and the potential of this model system to greatly increase the translatability of pre-clinical drug discovery in AD is shown.
Journal ArticleDOI
3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice.
Rebecca G. Canter,Wen-Chin Huang,Heejin Choi,Jun Wang,Lauren Ashley Watson,Christine G. Yao,Fatema Abdurrob,Stephanie M. Bousleiman,Jennie Z. Young,David A. Bennett,Ivana Delalle,Kwanghun Chung,Kwanghun Chung,Li-Huei Tsai +13 more
TL;DR: It is reported that subcortical memory structures show primary susceptibility to Aβ and that aggregates develop in increasingly complex networks with age, and it is found that Aβ accumulation in the mammillary body is linked to neuronal hyper-excitability and amyloid deposition can be reduced using a pharmacogenetics approach.
Journal ArticleDOI
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors.
Hiruy S. Meharena,Asaf Marco,Vishnu Dileep,Elana Lockshin,James Mullahoo,L. Ashley Watson,Tak Ko,Lindsey N Guerin,Fatema Abdurrob,Shruthi Rengarajan,Malvina Papanastasiou,Jacob D. Jaffe,Li-Huei Tsai +12 more
TL;DR: In this paper , the authors found that iPSC-derived neural progenitor cells (NPCs) exhibit genome-wide "chromosomal introversion," disruption of lamina-associated domains, and global chromatin accessibility changes in response to T21, consistent with the transcriptional and nuclear architecture changes characteristic of senescent cells.