R
Richard Rueda
Researcher at Picower Institute for Learning and Memory
Publications - 11
Citations - 2821
Richard Rueda is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Gene knockdown & Wnt signaling pathway. The author has an hindex of 9, co-authored 10 publications receiving 1974 citations. Previous affiliations of Richard Rueda include Massachusetts Institute of Technology.
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Journal ArticleDOI
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Hannah Iaccarino,Annabelle C. Singer,Anthony J Martorell,Anthony J Martorell,Andrii Rudenko,Andrii Rudenko,Fan Gao,Fan Gao,Tyler Z. Gillingham,Tyler Z. Gillingham,Hansruedi Mathys,Hansruedi Mathys,Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,Oleg Kritskiy,Fatema Abdurrob,Fatema Abdurrob,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Rebecca G. Canter,Rebecca G. Canter,Richard Rueda,Richard Rueda,Emery N. Brown,Edward S. Boyden,Edward S. Boyden,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +29 more
TL;DR: Reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.
Journal ArticleDOI
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Yuan-Ta Lin,Jinsoo Seo,Jinsoo Seo,Fan Gao,Heather M. Feldman,Hsin-Lan Wen,Jay Penney,Jay Penney,Hugh P. Cam,Hugh P. Cam,Elizabeta Gjoneska,Elizabeta Gjoneska,Waseem K. Raja,Waseem K. Raja,Jemmie Cheng,Jemmie Cheng,Richard Rueda,Oleg Kritskiy,Fatema Abdurrob,Zhuyu Peng,Blerta Milo,Chung Jong Yu,Sara Elmsaouri,Dilip Dey,Tak Ko,Bruce A. Yankner,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.
Journal ArticleDOI
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Ram Madabhushi,Fan Gao,Andreas R. Pfenning,Ling Pan,Satoko Yamakawa,Jinsoo Seo,Richard Rueda,Trongha X. Phan,Hidekuni Yamakawa,Ping-Chieh Pao,Ryan T. Stott,Elizabeta Gjoneska,Alexi Nott,Sukhee Cho,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai +17 more
TL;DR: It is reported that neuronal activity stimulation triggers the formation of DNA double strand breaks (DSBs) in the promoters of a subset of early-response genes, including Fos, Npas4, and Egr1.
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Ram Madabhushi,Andreas R. Pfenning,Fan Gao,Ling Pan,Satoko Yamakawa,Jinsoo Seo,Richard Rueda,Trongha X. Phan,Hidekuni Yamakawa,Ping-Chieh Pao,Ryan T. Stott,Elizabeta Gjoneska,Alexander Nott,Sukhee Cho,Manolis Kellis,Li-Huei Tsai +15 more
Journal ArticleDOI
Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Hannah Iaccarino,Annabelle C. Singer,Anthony J Martorell,Anthony J Martorell,Andrii Rudenko,Andrii Rudenko,Andrii Rudenko,Fan Gao,Fan Gao,Tyler Z. Gillingham,Tyler Z. Gillingham,Hansruedi Mathys,Hansruedi Mathys,Jinsoo Seo,Jinsoo Seo,Oleg Kritskiy,Oleg Kritskiy,Fatema Abdurrob,Fatema Abdurrob,Chinnakkaruppan Adaikkan,Chinnakkaruppan Adaikkan,Rebecca G. Canter,Rebecca G. Canter,Richard Rueda,Richard Rueda,Emery N. Brown,Edward S. Boyden,Edward S. Boyden,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +30 more
TL;DR: Reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer’s disease uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.