Zhuyu Peng

TL;DR: Single-cell transcriptomics from 48 individuals with varying degrees of Alzheimer's disease pathology demonstrates that gene-expression changes in Alzheimer’s disease are both cell-type specific and shared, and that transcriptional responses show sexual dimorphism.

TL;DR: Consistently, converting APOE4 to APOE3 in brain cell types from sAD iPSCs was sufficient to attenuate multiple AD-related pathologies and establishes a reference for human cell-type-specific changes associated with theAPOE4 variant.

TL;DR: In this Article, the Acknowledgements section should have included that the work was supported in part by the Cure Alzheimer’s Fund (CAF), and the final NIH grant acknowledged should have been ‘U01MH119509’ instead of ‘RF1AG054012’.

TL;DR: In this article , an iterative variant of expansion microscopy (the permeation of cells and tissues by a swellable hydrogel followed by isotropic hyrogel expansion, to allow for enhanced imaging resolution with ordinary microscopes) enables the imaging of nanostructures in expanded yet otherwise intact tissues.

TL;DR: This work developed a technology, expansion revealing (ExR), which isotropically decrowds proteins from each other, to enable their labeling, and uses it to discover the alignment of presynaptic calcium channels with postsynaptic machinery in intact brain circuits and periodic amyloid nanoclusters containing ion channel proteins in Alzheimer’s model mice.