Fazlul H. Sarkar

TL;DR: Findings suggest promising opportunities for gene therapies designed to enhance p21 expression or restore wild-type K-ras or p53 function in Pancreas cancer patients whose tumors express p21 show significant survival advantages when treated with chemotherapy or radiation therapy.

TL;DR: It is demonstrated that B-DIM augments radiation-induced cell killing and tumor growth inhibition and impairs critical survival signaling pathways activated by radiation, leading to enhanced cell killing.

TL;DR: Cytotoxicity of novel plumbagin hydrazones against estrogen and progesterone receptor positive (ER+/PR+) MCF-7 and triple negative MDA-MB-231 breast cancer cell lines is examined and these compounds can provide a starting point for the development of novel drug molecules against triple negative breast cancers.

TL;DR: This review provides comprehensive knowledge of the significance of Par-4 and its association with kras status in PC, along with the crosstalk with crucial resistance and survival molecules NF-κB and Bcl-2 that ultimately are responsible for the overall poor outcome of different therapeutic approaches in this disease.

TL;DR: In this article, the authors used ERRP (EGF-Receptor Related Protein) specific antibodies that could be used to study the functional properties of ERRP and as a diagnostic and prognostic tool for malignancies.