Federica Fusco

TL;DR: Pre-clinical data support a role for SIRT2 inhibition in the improvement of cognitive performance and the modulation of molecular mechanisms relevant for AD, thus deserving attention as possible therapeutic strategy.

TL;DR: It is demonstrated that progranulin (PGRN), a protein targeted to the classical secretory pathway, is also secreted in association with exosomes by human primary fibroblasts, and null mutations in the prog Granulin gene (GRN), a major cause of frontotemporal dementia, strongly reduce the number of released exosome and alter their composition.

TL;DR: Compound 7 may represent a promising tool for investigating NMDAR-mediated neurotoxic events involving Aβ burden and oxidative damage, and is able to modulate Aβ production.

TL;DR: Clinical factors associated with suicide in a sample of 553 mood disorder patients, recruited within the ‘Psy Pluriel’ center, Centre Européen de Psychologie Médicale, and the Department of Psychiatry of Erasme Hospital are investigated.

TL;DR: This work has tried to add complexity to the 3D cell culturing concept by using a microfluidic bioreactor, where cells are cultured under a continuous flow of medium, thus mimicking the interstitial fluid movement that actually perfuses the body tissues, including the brain.