Federica Mazzuca

TL;DR: Different mechanisms could be involved in sex differences with regard to immunotherapy and these differences could be relevant to identify immunological targets in order to draw studies exploring novel combinations of immunotherapy agents.

TL;DR: In this article, the main studies about clinical effects of several target inhibitors are reviewed, describing properly the most prominent mechanisms of both intrinsic and acquired resistance.

TL;DR: The new perspectives on the involvement of PD-1 and PDL-1 in the cross talk between gut microbiota and immune fitness and how gut microbiota impacts on the efficacy of anti-PD-1and-1 treatments in cancer are discussed.

TL;DR: Data confirm the role of the immune system in the neoplastic progression and in the response to therapy in TNBC and suggest that the expression of this biomarker could be associated with a subpopulation of TNBC more likely to respond to chemotherapy.

TL;DR: A nomogram based on easily available and inexpensive clinical factors showing a good performance in predicting individual OS probability among NSCLC patients treated with nivolumab is developed and could be valuable to clinicians in more accurately driving treatment decision in daily practice as well as enrollment onto clinical trials.