F
Federica Riu
Researcher at University of Bristol
Publications - 11
Citations - 871
Federica Riu is an academic researcher from University of Bristol. The author has contributed to research in topics: Angiogenesis & Progenitor cell. The author has an hindex of 9, co-authored 11 publications receiving 774 citations. Previous affiliations of Federica Riu include University of Otago & Bristol Royal Infirmary.
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Journal ArticleDOI
Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132
Rajesh Katare,Federica Riu,Kathryn Mitchell,Miriam Gubernator,Paola Campagnolo,Yuxin Cui,Orazio Fortunato,Elisa Avolio,Daniela Cesselli,Antonio Paolo Beltrami,Gianni D Angelini,Costanza Emanueli,Paolo Madeddu +12 more
TL;DR: SVP transplantation produces long-term improvement of cardiac function through a novel paracrine mechanism involving the secretion of miR-132 and inhibition of its target genes.
Journal ArticleDOI
Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair
Elisa Avolio,Marco Meloni,Helen L Spencer,Federica Riu,Rajesh Katare,Giuseppe Mangialardi,Atsuhiko Oikawa,Iker Rodriguez-Arabaolaza,Zexu Dang,Kathryn Mitchell,Carlotta Reni,Valeria Vincenza Alvino,Jonathan Rowlinson,Ugolino Livi,Daniela Cesselli,Gianni D Angelini,Costanza Emanueli,Antonio Paolo Beltrami,Paolo Madeddu +18 more
TL;DR: Combinatory therapy with SVPs and CSCs may complementarily help the repair of infarcted hearts.
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p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia
Andrea Caporali,Marco Meloni,Audrey Nailor,Tijana Mitić,Saran Shantikumar,Federica Riu,Graciela B. Sala-Newby,Lorraine Rose,Marie Besnier,Rajesh Katare,Christine Voellenkle,Paul Verkade,Fabio Martelli,Paolo Madeddu,Costanza Emanueli +14 more
TL;DR: The data demonstrate that miR-503 regulates pericyte–endothelial crosstalk in microvascular diabetic complications, and operation of the above mechanisms in mouse models of diabetes is confirmed.
Journal ArticleDOI
Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway
Pujika Emani Munasinghe,Federica Riu,Parul Dixit,Midori Edamatsu,Pankaj Saxena,Nathan S J Hamer,Ivor F. Galvin,Richard W. Bunton,Sharon Lequeux,Greg Jones,Regis R. Lamberts,Costanza Emanueli,Paolo Madeddu,Rajesh Katare +13 more
TL;DR: In-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death, demonstrating the pathological role of autophile in the type-2 diabetic heart.
Journal ArticleDOI
Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease
Elisa Avolio,Iker Rodriguez-Arabaolaza,Helen L Spencer,Federica Riu,Giuseppe Mangialardi,Sadie C. Slater,Jonathan Rowlinson,Valeria Vincenza Alvino,Oluwasomidotun O Idowu,Stephanie Soyombo,Atsuhiko Oikawa,Megan M. Swim,Cherrie H.T. Kong,Hongwei Cheng,Huidong Jia,Mohamed T. Ghorbel,Jules C. Hancox,Clive H. Orchard,Gianni D Angelini,Costanza Emanueli,Massimo Caputo,Paolo Madeddu +21 more
TL;DR: These findings open new avenues for cellular functionalization of prosthetic grafts to be applied in reconstructive surgery of congenital heart disease.