C
Costanza Emanueli
Researcher at National Institutes of Health
Publications - 246
Citations - 13432
Costanza Emanueli is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Angiogenesis & Progenitor cell. The author has an hindex of 63, co-authored 225 publications receiving 11685 citations. Previous affiliations of Costanza Emanueli include Tufts University & University of Sassari.
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Journal ArticleDOI
Methodological Guidelines to Study Extracellular Vesicles.
Frank A. W. Coumans,Alain Brisson,Edit I. Buzás,Françoise Dignat-George,Esther E.E. Drees,Samir El-Andaloussi,Samir El-Andaloussi,Costanza Emanueli,Costanza Emanueli,Aleksandra Gasecka,Aleksandra Gasecka,An Hendrix,Andrew F. Hill,Romaric Lacroix,Yi Lee,Ton G. van Leeuwen,Nigel Mackman,Imre Mäger,Imre Mäger,John P. Nolan,Edwin van der Pol,D. Michiel Pegtel,Susmita Sahoo,Pia Siljander,Guus Sturk,Olivier De Wever,Rienk Nieuwland +26 more
TL;DR: This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs.
Journal ArticleDOI
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA.
Iain M. Dykes,Costanza Emanueli +1 more
TL;DR: A model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes, and can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping.
Journal ArticleDOI
Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia
Andrea Caporali,Marco Meloni,Christine Vollenkle,Desireee Bonci,Graciela B. Sala-Newby,Roberta Addis,Gaia Spinetti,Sergio Losa,Rachel Masson,Andy Baker,Reuven Agami,Carlos le Sage,Gainluigi Condorelli,Paolo Madeddu,Fabio Martelli,Costanza Emanueli +15 more
TL;DR: The discovery that microRNA-503 expression in ECs is upregulated in culture conditions mimicking diabetes mellitus and ischemia-associated starvation and evidence that miR-503expression is increased in ischemic limb muscles of streptozotocin-diabetic mice and inECs enriched from these muscles are suggested.
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Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132
Rajesh Katare,Federica Riu,Kathryn Mitchell,Miriam Gubernator,Paola Campagnolo,Yuxin Cui,Orazio Fortunato,Elisa Avolio,Daniela Cesselli,Antonio Paolo Beltrami,Gianni D Angelini,Costanza Emanueli,Paolo Madeddu +12 more
TL;DR: SVP transplantation produces long-term improvement of cardiac function through a novel paracrine mechanism involving the secretion of miR-132 and inhibition of its target genes.
Journal ArticleDOI
Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential.
Paola Campagnolo,Daniela Cesselli,Ayman Al Haj Zen,Antonio Paolo Beltrami,Nicolle Kränkel,Rajesh Katare,Gianni D Angelini,Costanza Emanueli,Paolo Madeddu +8 more
TL;DR: SVPs generated from human vein CD34-positive/CD31-negative progenitor cells might represent a new therapeutic tool for angiogenic therapy in ischemic patients.