F
Fengwen Zhang
Researcher at Rockefeller University
Publications - 33
Citations - 3778
Fengwen Zhang is an academic researcher from Rockefeller University. The author has contributed to research in topics: Biology & Antibody. The author has an hindex of 16, co-authored 24 publications receiving 2439 citations. Previous affiliations of Fengwen Zhang include Aaron Diamond AIDS Research Center.
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Journal ArticleDOI
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants.
Yiska Weisblum,Fabian Schmidt,Fengwen Zhang,Justin DaSilva,Daniel Poston,Julio C. C. Lorenzi,Frauke Muecksch,Magdalena Rutkowska,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Christian Gaebler,Marianna Agudelo,Alice Cho,Zijun Wang,Anna Gazumyan,Melissa Cipolla,Larry L. Luchsinger,Christopher D. Hillyer,Marina Caskey,Davide F. Robbiani,Davide F. Robbiani,Charles M. Rice,Michel C. Nussenzweig,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz +26 more
TL;DR: It is shown that functional SARS-CoV-2 S protein variants with mutations in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected.
Posted ContentDOI
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Yiska Weisblum,Fabian Schmidt,Fengwen Zhang,Justin DaSilva,Daniel Poston,Julio C. C. Lorenzi,Frauke Muecksch,Magdalena Rutkowska,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Christian Gaebler,Marianna Agudelo,Alice Cho,Zijun Wang,Anna Gazumyan,Melissa Cipolla,Larry L. Luchsinger,Christopher D. Hillyer,Marina Caskey,Davide F. Robbiani,Davide F. Robbiani,Charles M. Rice,Michel C. Nussenzweig,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz +26 more
TL;DR: It is shown that functional SARS-CoV-2 S protein variants with mutations in the receptor binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected.
Journal ArticleDOI
Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists
Fengwen Zhang,Fengwen Zhang,Sam J. Wilson,Sam J. Wilson,Wilmina N. Landford,Beatriz Virgen,Devon A. Gregory,Marc C. Johnson,Jan Münch,Frank Kirchhoff,Paul D. Bieniasz,Paul D. Bieniasz,Theodora Hatziioannou +12 more
TL;DR: It is shown that the apparently "missing" antitetherin activity in SIVs has been acquired by several SIV Nef proteins, and a critical determinant of sensitivity to SIV(MAC) Nef in the tetherin cytoplasmic tail is variable in nonhuman primate tetherins and deleted in human tetherin, likely due to selective pressures imposed by viral antagonists.
Journal ArticleDOI
Identification of Interferon-Stimulated Genes with Antiretroviral Activity
Melissa Kane,Trinity Zang,Suzannah J. Rihn,Fengwen Zhang,Fengwen Zhang,Tonya Kueck,Tonya Kueck,Mudathir Alim,Mudathir Alim,John W. Schoggins,Charles M. Rice,Sam J. Wilson,Paul D. Bieniasz,Paul D. Bieniasz +13 more
TL;DR: Detailed analyses of two antiretroviral ISGs indicate that indoleamine 2,3-dioxygenase 1 (IDO1) can inhibit retroviral replication by metabolite depletion while tripartite motif-56 (TRIM56) accentuates ISG induction by IFNα and inhibits the expression of late HIV-1 genes.
Journal ArticleDOI
Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.
Zhiwei Chen,Linqi Zhang,Chuan Qin,Lei Ba,Christopher E. Yi,Fengwen Zhang,Qiang Wei,Tian He,Wenjie Yu,Jian Yu,Hong Gao,Xinming Tu,Agegnehu Gettie,Michael Farzan,Kwok-Yung Yuen,David D. Ho +15 more
TL;DR: The data suggest that a major mechanism for neutralizing SARS-CoV likely occurs through blocking the interaction between virus and the cellular receptor ACE2.