J
Justin DaSilva
Researcher at Rockefeller University
Publications - 23
Citations - 2718
Justin DaSilva is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 6, co-authored 8 publications receiving 1018 citations. Previous affiliations of Justin DaSilva include Howard Hughes Medical Institute.
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Journal ArticleDOI
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants.
Yiska Weisblum,Fabian Schmidt,Fengwen Zhang,Justin DaSilva,Daniel Poston,Julio C. C. Lorenzi,Frauke Muecksch,Magdalena Rutkowska,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Christian Gaebler,Marianna Agudelo,Alice Cho,Zijun Wang,Anna Gazumyan,Melissa Cipolla,Larry L. Luchsinger,Christopher D. Hillyer,Marina Caskey,Davide F. Robbiani,Davide F. Robbiani,Charles M. Rice,Michel C. Nussenzweig,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz +26 more
TL;DR: It is shown that functional SARS-CoV-2 S protein variants with mutations in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected.
Journal ArticleDOI
Vaccine Breakthrough Infections with SARS-CoV-2 Variants.
Ezgi Hacisuleyman,Caryn R Hale,Yuhki Saito,Nathalie E. Blachère,Marissa Bergh,Erin G. Conlon,Dennis Schaefer-Babajew,Justin DaSilva,Frauke Muecksch,Christian Gaebler,Richard P. Lifton,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Robert B. Darnell +14 more
TL;DR: In this paper, a cohort of 417 persons who had received the second dose of BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine at least 2 weeks previously, identified 2 women with vaccine breakthrough infection.
Posted ContentDOI
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Yiska Weisblum,Fabian Schmidt,Fengwen Zhang,Justin DaSilva,Daniel Poston,Julio C. C. Lorenzi,Frauke Muecksch,Magdalena Rutkowska,Hans-Heinrich Hoffmann,Eleftherios Michailidis,Christian Gaebler,Marianna Agudelo,Alice Cho,Zijun Wang,Anna Gazumyan,Melissa Cipolla,Larry L. Luchsinger,Christopher D. Hillyer,Marina Caskey,Davide F. Robbiani,Davide F. Robbiani,Charles M. Rice,Michel C. Nussenzweig,Michel C. Nussenzweig,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz +26 more
TL;DR: It is shown that functional SARS-CoV-2 S protein variants with mutations in the receptor binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected.
Journal ArticleDOI
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.
Alice Cho,Frauke Muecksch,Dennis Schaefer-Babajew,Zijun Wang,Shlomo Finkin,Christian Gaebler,Victor A. Ramos,Melissa Cipolla,Pilar Mendoza,Marianna Agudelo,Eva Bednarski,Justin DaSilva,Irina Shimeliovich,Juan Dizon,Mridushi Daga,Katrina G. Millard,Martina Turroja,Fabian Schmidt,Fengwen Zhang,Tarek Ben Tanfous,Mila Jankovic,Thiago Y. Oliveria,Anna Gazumyan,Marina Caskey,Paul D. Bieniasz,Paul D. Bieniasz,Theodora Hatziioannou,Michel C. Nussenzweig,Michel C. Nussenzweig +28 more
TL;DR: The authors examined memory B cell evolution 5 months after vaccination with either Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) mRNA vaccines in a cohort of SARS-CoV-2 naive individuals.
Journal ArticleDOI
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
Frauke Muecksch,Zhijun Wang,Alice Cho,Christian Gaebler,Tarek Ben Tanfous,Justin DaSilva,Eva Bednarski,Victor Ramos,Shuaizhou Zong,B J Johnson,Raphael Raspe,Dennis Schaefer-Babajew,Irina Shimeliovich,M. Daga,Kai-Hui Yao,Fabian Schmidt,Katrina G. Millard,Martina Turroja,Mila Jankovic,Thiago Y. Oliveira,Anna Gazumyan,Marina Caskey,Theodora Hatziioannou,Paul D. Bieniasz,Michel C. Nussenzweig +24 more
TL;DR: In this paper , the authors examined the memory B cell repertoire in a longitudinal cohort of individuals receiving three mRNA vaccine doses and found that the third dose is accompanied by an increase in, and evolution of, receptor-binding domain (RBD)-specific memory B cells.