Z
Zhiwei Chen
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 273
Citations - 14600
Zhiwei Chen is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 45, co-authored 206 publications receiving 10727 citations. Previous affiliations of Zhiwei Chen include Rockefeller University & China Meteorological Administration.
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Journal ArticleDOI
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
Kelvin K. W. To,Owen Tak Yin Tsang,Wai Shing Leung,Anthony Raymond Tam,Tak Chiu Wu,David Christopher Lung,Cyril C. Y. Yip,Jian Piao Cai,Jacky Man Chun Chan,Thomas Shiu Hong Chik,Daphne Pui-Ling Lau,Chris Yau Chung Choi,Lin Lei Chen,Wan Mui Chan,Kwok-Hung Chan,Jonathan Daniel Ip,Anthony Chin-Ki Ng,Rosana W.S. Poon,Cui Ting Luo,Vincent C.C. Cheng,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Ivan Hung,Zhiwei Chen,Honglin Chen,Kwok-Yung Yuen +25 more
TL;DR: The serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal saliva samples from patients with COVID-19, and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 are ascertained.
Journal ArticleDOI
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.
Lihong Liu,Pengfei Wang,Manoj S. Nair,Jian Yu,Micah Rapp,Qian Wang,Yang Luo,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Vincent Sahi,Amir Figueroa,Xinzheng V. Guo,Gabriele Cerutti,Jude Bimela,Jason Gorman,Tongqing Zhou,Zhiwei Chen,Zhiwei Chen,Kwok-Yung Yuen,Kwok-Yung Yuen,Peter D. Kwong,Peter D. Kwong,Joseph Sodroski,Michael T. Yin,Zizhang Sheng,Zizhang Sheng,Yaoxing Huang,Lawrence Shapiro,Lawrence Shapiro,David D. Ho +29 more
TL;DR: A diverse collection of potent neutralizing antibodies against the SARS-CoV-2 spike protein have been isolated from five patients with severe COVID-19 and high serum neutralization titres, suggesting both of these regions at the top of the viral spike are immunogenic.
Journal ArticleDOI
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility.
Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Anna Jinxia Zhang,Shuofeng Yuan,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Andrew Chak-Yiu Lee,Wan Mui Chan,Zhimeng Fan,Hoi Wah Tsoi,Lei Wen,Ronghui Liang,Jianli Cao,Yanxia Chen,Kaiming Tang,Cuiting Luo,Jian Piao Cai,Kin-Hang Kok,Hin Chu,Kwok-Hung Chan,Siddharth Sridhar,Siddharth Sridhar,Siddharth Sridhar,Zhiwei Chen,Honglin Chen,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Kwok-Yung Yuen,Kwok-Yung Yuen,Kwok-Yung Yuen +31 more
TL;DR: Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2.
Journal ArticleDOI
Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection
Li Liu,Qiang Wei,Qingqing Lin,Jun Fang,Haibo Wang,Hauyee Kwok,Hang Ying Tang,Kenji Nishiura,Jie Peng,Zhiwu Tan,Tongjin Wu,Ka-Wai Cheung,Kwok-Hung Chan,Xavier Alvarez,Chuan Qin,Andrew A. Lackner,Stanley Perlman,Kwok-Yung Yuen,Zhiwei Chen +18 more
TL;DR: It is determined that anti-spike IgG (S-IgG), in productively infected lungs, causes severe ALI by skewing inflammation-resolving response and providing a potential target for treatment of SARS-CoV or other virus-mediated lung injury.
Journal ArticleDOI
Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5
Yicheng Guo,Sho Iketani,Manoj S. Nair,Zhiteng Li,Hiroshi Mohri,Maple Wang,Jian Yu,Anthony D. Bowen,Jennifer S. Chang,Jayesh Shah,Nadia Nguyen,Zhiwei Chen,Kathrine Meyers,Michael T. Yin,Magdalena E. Sobieszczyk,Zizhang Sheng,Yaoxing Huang,Lihong Liu,David D. Ho +18 more
TL;DR: A systematic antigenic analysis of the SARS-CoV-2 Omicron subvariants BA.12.2.1 and BA.4.4/5 was performed in this article .