Filomena de Nigris

TL;DR: L-Arginine, the precursor of NO, has demonstrated beneficial effects in atherosclerosis and disturbed shear stress, and eNOS gene polymorphism might be an additional risk factor that may contribute to predict cardiovascular events.

TL;DR: The results support the concept that p66Shc−/− may play a pivotal role in controlling systemic oxidative stress and vascular diseases and suggest it might represent a molecular target for therapies against vascular diseases.

TL;DR: Because hypercholesterolemia exerts pro‐oxidant effects both intra‐ and extracellularly and because increased ROS formation affects vascular reactivity and atherogenesis by modulating multiple signaling pathways and transcriptional events, future investigations of its atherogenic mechanisms should place greater emphasis on the net effect of such modulation on the expression of a large spectrum of genes.

TL;DR: It is demonstrated that mildly oxidized LDL generated by incubation with oxygen radical‐producing xanthine/xanthine oxidase (X/XO) induces apoptosis in primary cultures of human coronary endothelial and SMC, as determined by TUNEL technique, DNA laddering, and FACS analysis.

TL;DR: The results indicate that activation of the NFκB complex by overexpression of p65 plays a critical role in the process of thyroid cell transformation.