S
Sabrina Battista
Researcher at Thomas Jefferson University
Publications - 30
Citations - 2660
Sabrina Battista is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 20, co-authored 25 publications receiving 2510 citations. Previous affiliations of Sabrina Battista include University of Naples Federico II.
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Journal Article
High level expression of the HMGI (Y) gene during embryonic development.
Gennaro Chiappetta,Virginia Avantaggiato,Roberta Visconti,Monica Fedele,Sabrina Battista,Francesco Trapasso,Bianca Maria Merciai,Vincenzo Fidanza,Vincenzo Giancotti,Massimo Santoro,Antonio Simeone,Alfredo Fusco +11 more
TL;DR: It is demonstrated that the HMGI (Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed in high levels comparable to those detected in neoplastic tissues.
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The effect of matrix composition of 3D constructs on embryonic stem cell differentiation
Sabrina Battista,Daniela Guarnieri,Cristina Borselli,S. Zeppetelli,Assunta Borzacchiello,Laura Mayol,Diego Gerbasio,Douglas R. Keene,Luigi Ambrosio,Paolo A. Netti +9 more
TL;DR: The data suggest that matrix composition has an important role in EBs development and that it is possible to influence stem cell differentiation toward preferential pattern, by modulating the physical and biochemical properties of the scaffold.
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HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Monica Fedele,Rosa Visone,Ivana De Martino,Giancarlo Troncone,Dario Palmieri,Sabrina Battista,Andrea Ciarmiello,Pierlorenzo Pallante,Claudio Arra,Rosa Marina Melillo,Kristian Helin,Carlo M. Croce,Alfredo Fusco +12 more
TL;DR: It is shown that HMGA2 interacts with pRB and induces E2F1 activity in mouse pituitary adenomas by displacing HDAC1 from the pRB/E2F 1 complex-a process that results in E2f1 acetylation.
Journal Article
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Sabrina Battista,Vincenzo Fidanza,Monica Fedele,Andres J. Klein-Szanto,Eric Outwater,Han Brunner,Massimo Santoro,Carlo M. Croce,Alfredo Fusco +8 more
TL;DR: Transgenic mice carrying a HMGI-C construct, containing only the three AT-hook domains, showed a giant phenotype, together with a predominantly abdominal/pelvic lipomatosis, suggesting a pivotal role of the HM GI-C truncation in the generation of human lipomas.
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Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
Monica Fedele,Monica Fedele,Sabrina Battista,Sabrina Battista,Lawrence C. Kenyon,Gustavo Baldassarre,Vincenzo Fidanza,Andres J. Klein-Szanto,Albert F. Parlow,Rosa Visone,Giovanna Maria Pierantoni,Eric Outwater,Massimo Santoro,Carlo M. Croce,Alfredo Fusco +14 more
TL;DR: It is demonstrated that the overexpression of HMGA2 leads to the onset of mixed growth hormone/prolactin cell pituitary adenomas, and these transgenic mice may represent an important tool for the study of this kind of neoplasia.