F
Firas Fadel
Researcher at University of Strasbourg
Publications - 4
Citations - 107
Firas Fadel is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Protein domain & Catalytic triad. The author has an hindex of 4, co-authored 4 publications receiving 85 citations. Previous affiliations of Firas Fadel include French Institute of Health and Medical Research.
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Journal ArticleDOI
X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain.
TL;DR: The new CHIT1-FL structure, determined with an adapted crystallization approach, is one of the few complete bi-modular chitinase structures available and reveals the structural features of a human CBM14 domain.
Journal ArticleDOI
High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution.
Eduardo Howard,Benoit Guillot,Matthew P. Blakeley,Michael Haertlein,M. Moulin,Andre Mitschler,Alexandra Cousido-Siah,Firas Fadel,W.M. Valsecchi,Takashi Tomizaki,Tatiana Petrova,J. Claudot,Alberto Podjarny +12 more
TL;DR: Neutron and high-resolution X-ray crystallography were used to determine fully the structure of the internal water cluster in H-FABP and showed significant alignment of the permanent dipoles of the water molecules with the protein electrostatic field.
Journal ArticleDOI
New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Firas Fadel,Yuguang Zhao,Raul E Cachau,Alexandra Cousido-Siah,F.X. Ruiz,Karl Harlos,Eduardo Howard,Andre Mitschler,Alberto Podjarny +8 more
TL;DR: A new mechanism involving changes in the conformation and protonation state of the catalytic triad, as well as a new role for Tyr27 are suggested, providing new insights into the hydrolysis and transglycosylation activities.
Journal ArticleDOI
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
Marzena Mazur,Jacek Olczak,Sylwia Olejniczak,Robert Koralewski,Czestkowski Wojciech J,Anna Jedrzejczak,Jakub Golab,Karolina Dzwonek,Barbara Dymek,Piotr L. Sklepkiewicz,Agnieszka Zagozdzon,Tom Noonan,Keyvan Mahboubi,Bruce R. Conway,Ryan Sheeler,Paul Beckett,William M. Hungerford,Alberto Podjarny,Andre Mitschler,Alexandra Cousido-Siah,Firas Fadel,Adam Golebiowski +21 more
TL;DR: Therapeutic efficacy of compound 7f in the clinically relevant aeroallergen-induced acute asthma model in mice provides a rationale for developing AMCase inhibitor for the treatment of asthma.